On the mechanism of the splay in the glucose titration curve in advanced experimental renal disease in the rat

The Journal of Clinical Investigation
S W ShankelN S Bricker

Abstract

Glucose titration studies were performed in rats with unilateral chronic pyelonephritis before and after removal of the contralateral control kidneys. Identical studies were performed in animals with unilateral partial renal infarction in which the experimental kidneys had a marked reduction in nephron population but no anatomic deformation in the surviving nephrons. In the initial studies, both groups of animals were free of clinical and chemical abnormalities of uremia. In the follow-up studies uremic abnormalities were present. Minimal splay was observed in the titration curves in the initial studies; marked splay was present in the group data from the same kidneys in the subsequent studies. Thus a marked reduction in the nephron population was associated with the evolution of splay in both groups of animals. In association with the increase in splay, the mean values for maximal glucose transport increased; thus a defect in glucose transport can be excluded as the basis of the splay. Glomerular filtration rate increased proportionately more than the maximal transport of glucose; hence the ratios of glomerular filtration rate to maximal glucose transport increased consistently. The possibility of asymmetric hypertrophy of glo...Continue Reading

References

Feb 1, 1967·The Journal of Clinical Investigation·R E RieselbachN S Bricker
Oct 1, 1964·The Journal of Clinical Investigation·N S BRICKERR E RIESELBACH

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Citations

Jan 1, 1983·Urological Research·R F Gagnon, W P Duguid
May 23, 1998·European Journal of Pharmacology·T YamanouchiH Miyashita
Feb 29, 1968·The New England Journal of Medicine·L W HendersonM Goldberg
Apr 23, 1970·The New England Journal of Medicine·J P Merrill, C L Hampers
Feb 1, 1967·The Journal of Clinical Investigation·R E RieselbachN S Bricker
Feb 1, 1968·The Journal of Clinical Investigation·A M RobsonN S Bricker
Apr 1, 1968·The Journal of Clinical Investigation·J J McPhaul, J J Simonaitis
Sep 1, 1969·The Journal of Clinical Investigation·M L PurkersonN S Bricker
Jun 1, 1972·The Journal of Clinical Investigation·J J BourgoignieN S Bricker
Aug 1, 1975·The Journal of Clinical Investigation·G H Espinel
Apr 1, 1984·The Journal of Clinical Investigation·V M VehaskariA M Robson
Dec 1, 1985·The Journal of Clinical Investigation·B R ColeP Needleman
Jul 1, 1978·Kidney International·J BoudetJ L Funck-Brentano
May 1, 1976·Kidney International·M L PurkersonS Klahr
Jun 1, 1976·Kidney International·J A ArrudN A Kurtzman
Feb 1, 1982·The American Journal of Medicine·M G Cogan
Jun 1, 1969·The American Journal of Medicine·R B MillerW B Schwartz
Dec 1, 1967·The American Journal of Medicine·T H Steele, R E Rieselbach
Jan 1, 1969·The American Journal of Medicine·N S Bricker
Oct 1, 1975·Scandinavian Journal of Clinical and Laboratory Investigation·A Fredriksson
May 8, 2020·Journal of Diabetes Research·Ricardo Pereira-Moreira, Elza Muscelli
Sep 1, 1979·Kidney International·A M RobsonN S Bricker

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