On the metabolism of allopurinol. Formation of allopurinol-1-riboside in purine nucleoside phosphorylase deficiency

Biochemical Pharmacology
S ReiterA R Watson

Abstract

Allopurinol-1-riboside, a major metabolite of allopurinol, is commonly thought to be directly synthesized by purine nucleoside phosphorylase (PNP) in vivo. As this enzyme is otherwise believed to function in vivo primarily in the direction of nucleoside breakdown, we have determined by high performance liquid chromatography and a conventional chromatographic method the urinary metabolites of allopurinol in a child deficient of PNP. In this patient approximately 40% of urinary allopurinol metabolites consisted of allopurinol-1-riboside, thus proving the possibility of indirect formation of allopurinol-1-riboside via allopurinol-1-ribotide in vivo, catalysed by hypoxanthine guanine phosphoribosyltransferase (HGPRT) and a phosphatase.

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Citations

Mar 9, 1987·FEBS Letters·P C MoorhouseJ M Gutteridge
Jan 1, 1987·Free Radical Research Communications·M GrootveldC P Moorhouse
Sep 26, 1985·The New England Journal of Medicine·W G BerlingerR Spector
Sep 1, 1991·Annals of the Rheumatic Diseases·T YamamotoK Higashino
Mar 1, 2018·The Journal of Biological Chemistry·J Scott LeeSean P Colgan
Mar 15, 1990·Clinica Chimica Acta; International Journal of Clinical Chemistry·S ReiterM Knedel

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