PMID: 9019Jan 1, 1976

On the morphology of the human Sertoli cells under normal conditions and in patients with impaired fertility

Andrologia
C SchulzeF Körner

Abstract

Sertoli cells in testicular biopsies from 7 patients with Sertoli-cell only syndrome, 8 patients who had been treated with cyclophosphamide for testicular neoplasia, 8 patients with oligozoospermia, 7 patients with cryptorchidism, and 8 patients with seminoma were examined under the electron microscope and compared with Sertoli cells of normal tissues. The investigations reveal that each of these conditions of impaired fertility is characterized of a special type of Sertoli cell. The cell pattern is either restricted to one or two of the normally occurring cell types, or modified cells predominate that might be typical of the underlying disturbances of spermatogenesis. It is suggested that the cell type which prevails in the Sertoli-cell only syndrome is capable of maintaining a basic production of a substance that inhibits FSH secretion.

References

Jan 1, 1975·Acta Endocrinologica·P Christiansen
Jun 3, 1972·Lancet·R KumarM G McGeown
Aug 3, 1973·Zeitschrift für Zellforschung und mikroskopische Anatomie·E Bustos-Obregón, A F Holstein
Jan 1, 1974·Cell and Tissue Research·C Schulze
Apr 1, 1972·The Journal of Clinical Investigation·D H Van ThielV T De Vita
May 1, 1974·The Journal of Clinical Endocrinology and Metabolism·D M De KretserB Hudson
Jan 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J M LeonardC A Paulsen
Jun 1, 1972·The Journal of Clinical Endocrinology and Metabolism·P FranchimontA Netter
Sep 1, 1972·The Journal of Clinical Endocrinology and Metabolism·D M De KretserH P Taft
Mar 1, 1971·The Journal of Clinical Endocrinology and Metabolism·S W Rosen, B D Weintraub
Jan 1, 1966·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Nagano
Dec 1, 1963·Journal of Ultrastructure Research·S R BAWA
Jul 1, 1965·The Journal of Clinical Endocrinology and Metabolism·R E MANCINIJ A ANDRADA

Related Concepts

Unilateral Cryptorchidism
Dysgerminoma
Oligospermia
Structure of Sertoli Cell
Testicular Diseases
Malignant Neoplasm of Testis

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