On the nature of basal vascular tone in cat skeletal muscle and its dependence on transmural pressure stimuli

Acta Physiologica Scandinavica
P O GrändeS Mellander

Abstract

The aim of the present study was to elucidate in some detail the characteristics of the intrinsic basal vascular tone in the adrenergically blocked skeletal muscle with regard to its extent and site along the vascular bed, its dependence on arterial pressure via static and dynamic transmural pressure stimuli, and its sensitivity to local metabolic influence. Basal tone, which apparently is of myogenic nature, was pronounced in 'proximal arterial vessels' (greater than 25 mmicrometer i.d.) and in the 'microvessels' (less than 25 micrometers), but low in 'large veins'. Its functional characteristics, however, were different in the 'proximal arterial vessels' and the 'microvessels'. Normal basal tone in the 'microvessels' thus seemed to be intimately dependent on the arterial blood pressure level and, at least partly, initiated by its static mean pressure distension effect as well as by its dynamic pulse pressure oscillations. It could be virtually abolished by a transmural pressure decrease applied at fast rate ('strong inhibitory dynamic transmural pressure stimulus'). Basal tone in the 'proximal arterial vessels', on the other hand, was little affected by arterial pressure and almost irresponsive to transmural pressure stimuli....Continue Reading

References

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Citations

Jan 1, 1990·Intensive Care Medicine·P O GrändeL Lindberg
Jan 1, 1996·Annals of Biomedical Engineering·S Cavalcanti, M Ursino
May 28, 2008·Lasers in Medical Science·Hsin HsiuYuh-Ying Lin Wang
Mar 1, 1982·Acta Physiologica Scandinavica·S MellanderP Hellstrand
Dec 1, 1982·Acta Physiologica Scandinavica·P BorgströmS Mellander
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Aug 1, 1983·Pflügers Archiv : European journal of physiology·I R Wendt, D G Stephenson
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Related Concepts

Adrenergic alpha-Antagonists
Adrenergic beta-Antagonists
Arteries
Diastolic Blood Pressure
Felis catus
Microcirculation
Inotropism
Muscle Tonus
Muscle, Smooth, Vascular
Pulse Taking

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