PMID: 107974Jan 1, 1979

On the nature of tetracycline resistance in Bacillus subtilis mediated by the plasmid pT 127

Biochimie
F FargetteG Rapoport

Abstract

The nature of tetracycline resistance was studied in a strain of Bacillus subtilis carrying the plasmid pT 127 in comparison with the parental strain. The resistance has been shown to be inducible in both strains upon exposure to subinhibitory concentrations of tetracycline. No modification of the protein-synthesizing activity of the ribosomes or intracellular inactivation of the antibiotic was observed in both strains. Accumulation of labeled tetracycline in B. subtilis was found to be particularly low in the wild-type strain, compared to other bacterial species, with concentration gradients of only 2 to 3 fold. From the kinetics obtained it is likely that the permeation of the antibiotic does not correspond to an active process in B. subtilis. A fairly good correlation was established between the level of resistance obtained after induction or by the presence of the plasmid pT 127 and a decrease in the binding capacity of the cell for the antibiotic.

References

Apr 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S D Ehrlich
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·K M KegginsE J Duvall
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T J Gryczan, D Dubnau
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S D Ehrlich
May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H L YangS B Levy
May 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·D B ClewellB Bauer
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·C Ruby, R P Novick
May 1, 1975·Journal of General Microbiology·E H Asheshov
Feb 1, 1969·Journal of General Microbiology·R H Connamacher
Jun 1, 1973·Antimicrobial Agents and Chemotherapy·N A Kuck, M Forbes
Feb 18, 1969·Biochimica Et Biophysica Acta·B L Hutchings

Related Concepts

Natto Bacteria
Bacterial Proteins
Genes, Spliced
Antibiotic Resistance, Microbial
Episomes
Poly U
Ribosomes
Staphylococcus aureus
Tetrabid
Protein Biosynthesis

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.