PMID: 7529115Sep 1, 1994Paper

On the nature of the 5-HT receptor subtype inhibiting acetylcholine release in the guinea-pig ileum

British Journal of Pharmacology
M J RamírezB Lasheras

Abstract

1. The nature of the 5-hydroxytryptamine (5-HT) receptor subtype controlling acetylcholine release and contraction induced by stimulation of the neurokinin NK3 receptor has been studied in the longitudinal muscle-myenteric plexus preparation from guinea-pig ileum. 2. In preparations preloaded with [3H]-choline, the selective NK3 agonist, senktide, produced a concentration-dependent increase in tritium overflow, an index of [3H]-acetylcholine release. Low concentrations of neurokinin B, also markedly increased tritium efflux. 3. The senktide-induced acetylcholine release was markedly increased by the same concentration of methysergide and mesulergine. The 5-HT2A/2C agonist DOI (1 microM) inhibited the tritium overflow while 8-OH-DPAT, sumatriptan and ketanserin (1 microM each) were without effect on the senktide-induced tritium efflux. 4. The contractile response to senktide in the guinea-pig ileum was attenuated by atropine, 0.1 microM. Methysergide, a 5-HT1/2 receptor antagonist, and mesulergine, a 5-HT2A/2B/2C receptor antagonist, (1 microM each), enhanced the contractile effect of the NK3 receptor agonist. 5. It is concluded that the acetylcholine release induced by a NK3 receptor agonist is inhibited by stimulation of a 5-H...Continue Reading

References

Feb 1, 1976·Canadian Journal of Physiology and Pharmacology·J C Szerb
Jan 1, 1991·Annals of the New York Academy of Sciences·S GuardS P Watson
Jan 1, 1991·Journal of Receptor Research·D Hoyer, P Schoeffter
Feb 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·W U DompertJ Traber
Mar 18, 1986·European Journal of Pharmacology·R E HeuringS J Peroutka
Jun 1, 1985·British Journal of Pharmacology·H Kilbinger, I Pfeuffer-Friederich
Jun 1, 1993·Trends in Pharmacological Sciences·P P HumphreyD Hoyer

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Citations

Jul 4, 2012·Journal of Chemical Information and Modeling·Violeta I Pérez-NuenoDavid W Ritchie
Nov 7, 2006·Journal of Neuropathology and Experimental Neurology·Monica Garcia-AllozaMaria Javier Ramirez
Dec 1, 2011·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Yiyi WangUy Dong Sohn
Apr 19, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elena Fiorica-HowellsMichael D Gershon

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