PMID: 6025323Jun 1, 1967Paper

On the nature of transplantation immunity in the adenovirus tumor system

The Journal of Experimental Medicine
L D Berman

Abstract

The existence of a virus-induced, virus-specific transplantation, antigen in adenovirus 12-induced CBA mouse tumors was demonstrated. The antigen is virus-specific, but not related to structural virion or T antigens. It is a weak antigen, and required immunization with whole, infectious adenovirus 12 to produce considerable immunity. Comparable immunity could not be achieved with homologous cellular or subcellular materials, but some indication of enhancement was produced with low tumor dose. Immunization required at least 2 wk and was mediated by immune lymphoid cells. Serum of immunized animals showed no demonstrable cytotoxicity or enhancement. Animals immunized with virus and Freund's adjuvant showed diminished transplantation immunity, although these animals were actively immunized against adenovirus type 12 structural virion antigens.

References

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Citations

Jan 1, 1973·Archiv für die gesamte Virusforschung·R C Rees, C W Potter
Jan 1, 1969·Archiv für die gesamte Virusforschung·C W PotterJ S Oxford
Jan 1, 1971·Archiv für die gesamte Virusforschung·A M PotterJ S Oxford
Jan 1, 1980·Pharmacology & Therapeutics·L Carrasco, A E Smith
Feb 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R C ReesJ Shelton
Sep 15, 1968·International Journal of Cancer. Journal International Du Cancer·J H DarbyshireH G Pereira
Jan 1, 1974·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·N SeemayerG Seemayer
Jan 15, 1969·International Journal of Cancer. Journal International Du Cancer·C J Croft
Jan 1, 1969·Archiv für die gesamte Virusforschung·C W PotterJ M Hoskins
May 15, 1969·International Journal of Cancer. Journal International Du Cancer·J Ankerst, H O Sjögren
Nov 15, 1970·International Journal of Cancer. Journal International Du Cancer·C W Potter, J S Oxford
Oct 15, 1974·International Journal of Cancer. Journal International Du Cancer·G Parmiani, R Lembo
Jul 16, 1976·Biochimica Et Biophysica Acta·F Rapp, D Westmoreland
Feb 1, 1972·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E G BrownJ S Oxford

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