On the Need of Objective Vigilance Monitoring: Effects of Sleep Loss on Target Detection and Task-Negative Activity Using Combined EEG/fMRI.

Frontiers in Neurology
Michael CzischS P Drummond

Abstract

Sleep loss affects attention by reducing levels of arousal and alertness. The neural mechanisms underlying the compensatory efforts of the brain to maintain attention and performance after sleep deprivation (SD) are not fully understood. Previous neuroimaging studies of SD have not been able to separate the effects of reduced arousal from the effects of SD on cerebral responses to cognitive challenges. Here, we used a simultaneous electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) approach to study the effects of 36 h of total sleep deprivation (TSD). Specifically, we focused on changes in selective attention processes as induced by an active acoustic oddball task, with the ability to isolate runs with objective EEG signs of high (SD(alert)) or reduced (SD(sleepy)) vigilance. In the SD(alert) condition, oddball task-related activity appears to be sustained by compensatory co-activation of insular regions, but task-negative activity in the right posterior node of the default mode network is altered following TSD. In the SD(sleepy) condition, oddball task-positive activity was massively impaired, but task-negative activation was showing levels comparable with the control condition after a well-rested ni...Continue Reading

Citations

Dec 8, 2015·Biological Psychology·Antonio Luque-CasadoDaniel Sanabria
Apr 7, 2016·Proceedings of the National Academy of Sciences of the United States of America·Catie ChangJeff H Duyn
May 6, 2015·Annals of Neurology·Micheline MaireChristina Schmidt
May 3, 2014·Behavioral Sleep Medicine·Erin L AlmklovOmar M Alhassoon
May 19, 2017·Nature Reviews. Neuroscience·Adam J KrauseMatthew P Walker
Sep 19, 2017·Sleep & Breathing = Schlaf & Atmung·Jessica A ChristianszSarah N Biggs
Sep 3, 2013·Sleep·Sean P A DrummondLaura D Straus
Nov 12, 2015·Frontiers in Human Neuroscience·Chih-Sheng HuangChin-Teng Lin
Feb 24, 2017·Brain Topography·E A AllenV D Calhoun
Jul 18, 2017·Brain Topography·Laura TüshausPeter Achermann
Jul 28, 2020·Frontiers in Behavioral Neuroscience·Xuewei ChenQiang Ma

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