On the noradrenaline loading in axonal amine storage granules in rat crushed sciated nerves.

Acta Physiologica Scandinavica
A DahlströmP A Larsson

Abstract

The increase of NA in rat sciatic nerve above a crush was investigated. The transported amounts of NA did not increase quite linearly with time, but more NA was found above the crush at 6 and 12 h than would be expected from the 3 h value. One possible reason for this phenomenon--an increased NA loading of the accumulated axonal granules--was investigated by 2 types of double crush experiments. One type involved simultaneous double crushes 1-1.5 cm apart. The increase in NA in the isolated segment 6 h after crushing indicated that the axonal amine storage granules had increased their NA load by about 70%. In the second type ("delayed double crushes") a distal crush was made 6 h before a second crush, 1-1.5 cm proximal to the first crush. 1-12 h after the second high crush the NA content of the isolated segment was assayed. The results indicated an increased NA content in the axonal granules of 75% already 3-4 h after the isolation of the segment, remaining constant up to 9 h after the second crush. The results indicate that axonal storage granules may increase their NA content by a factor of about 2 (1.7) while being transported distally in the axons. This information together with the information from the preceding article of ...Continue Reading

References

Jul 1, 1975·Acta Physiologica Scandinavica·J HäggendalP A Larsson
Jun 17, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A Dahlström
May 1, 1973·Journal of Neurochemistry·G F Wooten, J T Coyle
Mar 28, 1967·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·K Kapeller, D Mayor
Apr 1, 1972·European Journal of Pharmacology·W G McLean, P Keen
Oct 1, 1969·The Journal of Physiology·L B Geffen, A Ostberg
Jul 1, 1966·Acta Physiologica Scandinavica·A Dahlström, J Häggendal
May 15, 1964·Zeitschrift für Zellforschung und mikroskopische Anatomie·A DAHLSTROEM, K FUXE
Oct 1, 1959·The Journal of Comparative Neurology·L LUBINSKA

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Citations

Jul 1, 1975·Acta Physiologica Scandinavica·J HäggendalP A Larsson
Jul 1, 1982·Brain Research Bulletin·A DahlströmP A Larsson
Dec 17, 2009·Progress in Neurobiology·Annica B Dahlstrom
Jul 1, 1989·Journal of Microscopy·A DahlströmP A Larsson

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