PMID: 3773571Aug 1, 1986Paper

On the ontogeny and interactions of glyceraldehyde-3-phosphate dehydrogenase

Mechanisms of Ageing and Development
S Reid, C Masters

Abstract

The interaction of GAPDH with cellular structure has been studied in the major tissues of the mouse during development. Overall the data provides a clear indication that interactions between GAPDH and cellular structure are appreciable in all major tissues, at least during early stages of development, and an analysis of the isozyme status of the enzyme in both soluble and bound compartments for all tissues at all developmental stages indicates the presence of only a single GAPDH isozyme in the mouse. Possible reasons for the lack of an extensive multiplicity of this enzyme in mammalian tissues (the only tetrameric glycolytic enzyme to display this restriction) and for the large amounts of GAPDH in many cell types are discussed in relation to the large number of proteins that GAPDH interacts with in the cell.

References

Jul 1, 1976·Annals of Human Genetics·Y H EdwardsH Harris
Jan 12, 1978·Biochimica Et Biophysica Acta·H R Knull
Feb 1, 1986·Mechanisms of Ageing and Development·S Reid, C Masters
May 31, 1985·Mechanisms of Ageing and Development·S Reid, C Masters
Jun 1, 1985·Mechanisms of Ageing and Development·S Reid, C Masters
Jul 1, 1985·Mechanisms of Ageing and Development·S Reid, C Masters
Sep 19, 1969·Science·W A SusorW J Rutter
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H N AithalF G Toback
Jan 1, 1980·Archives of Biochemistry and Biophysics·D R Yeltman, B G Harris
Jan 1, 1980·Journal of Neurochemistry·H R KnullW G Niehaus
Jan 1, 1981·CRC Critical Reviews in Biochemistry·C J Masters
Nov 30, 1982·Biochemical and Biophysical Research Communications·F M Clarke, D J Morton
Oct 1, 1981·Biochemical Society Transactions·C T Jones
Jul 1, 1981·Canadian Journal of Biochemistry·W W Bronstein, H R Knull
Oct 1, 1981·European Journal of Biochemistry·A R MacLeod

❮ Previous
Next ❯

Citations

Nov 15, 1991·Mechanisms of Ageing and Development·C Masters

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.