On the optimization of local hyperthermy in tumors based on a new radiofrequency procedure. Local hyperthermy of large body areas using the CMT selectotherm method

Journal of Cancer Research and Clinical Oncology
M von ArdenneE Kell

Abstract

A new radiofrequency procedure, i.c., the CMT Selectotherm technique, permits to convey large heat quantities per volume unit also to deep-seated tumor tissues without causing thermal lesions in healthy tissues near or at the body surface. The improved spatial homogeneity of energy supply attainable by this method is demonstrated by measurements at a gelatine phantom and, in particular, by in vivo measurements on pigs. The appliability of local hyperthermy to tumors localized in different parts of the body is substantially improved (a) by the principle of superimposing local hyperthermy on an elevated temperature level of metabolically induced whole-body hyperthermy (CMT-spontaneous hyperthermy at 40 degrees C) and (b) by the principle of selective increasing the thermal sensitivity of tumor tissues by decreasing the pH in these areas (the CMT main step). It is shown that the temperature dose T. deltat necessary for the selective occlusion of the vasculature in tumor tissues can be obtained by the CMT Selectotherm process also in deep-seated tumors. This process is part of the 1977 CMT concept. The fundamentals of optimizing local hyperthermy with consideration of heat dissipation from the tissue by heat conduction and convecti...Continue Reading

References

Jan 1, 1983·Annals of the New York Academy of Sciences·A L Copley
Jan 1, 1980·Annals of the New York Academy of Sciences·M von Ardenne, W Krüger
Jan 1, 1982·Journal of Cancer Research and Clinical Oncology·M von Ardenne, P G Reitnauer

Citations

Sep 30, 1977·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M von Ardenne, A von Ardenne
Mar 1, 1978·Die Naturwissenschaften·M von Ardenne, P G Reitnauer
Sep 1, 1962·Annals of Surgery·W W SHINGLETON

Related Concepts

Energy Supply
Pathological Fracture
Neoplasms
Biobatteries
Obstruction
Epilepsies, Partial
Heat Dissipation
Thermal Conductivity
Dental Occlusion
Spherocyte Count

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