On the origin of EDSS

Multiple Sclerosis and Related Disorders
J F Kurtzke

Abstract

The origin of EDSS, the Expanded Disability Status Scale for multiple sclerosis, was some 30 years before its only publication in 1983 when we were trying to assess a potential treatment and found no published methods. Findings from the complete neurologic examinations in over 200 patients were consolidated into mutually exclusive but all-inclusive neurophysiologic entities called Functional Systems (FS), and these provided the basis for an 11 step 0-10 rank order scale, the Disability Status Scale (DSS). This was used successfully, as well as in the first two Class I treatment trials performed, with the second one also incorporating the 8 FS. Both measures were part of an assessment of a natural history series derived from men hospitalized for MS in the US Army in World War II and followed for some 20 years. Describing each of the 8 FS as affected (1) or normal (0) defined 256 possible patterns of involvement for all patients. Half the patients at diagnosis had one of the 14 most common patterns. Each FS worsened in frequency and severity of involvement in correlation with the DSS, which overall showed a unimodal distribution, until in another series of patients 16 years post onset bimodality first appeared. Observations that ...Continue Reading

References

Jan 1, 1970·Acta Neurologica Scandinavica·J F Kurtzke
Jan 1, 1984·Annals of the New York Academy of Sciences·J F Kurtzke
Aug 1, 1956·A.M.A. Archives of Neurology and Psychiatry·J F KURTZKE
Jan 19, 1957·Journal of the American Medical Association·L BERLIN, J F KURTZKE

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Citations

Feb 10, 2016·Multiple Sclerosis and Related Disorders·Brenda BanwellFred Lublin
May 27, 2015·Multiple Sclerosis and Related Disorders·Ludwig KapposCarmen Lienert
May 25, 2016·Expert Review of Neurotherapeutics·Robert W Motl, Lara A Pilutti
Jul 3, 2016·Human Movement Science·Matthew B DownerMichelle Ploughman
Aug 16, 2017·Acta neurologica Belgica·Bedile Irem TiftikciogluFigen Tokucoglu
Aug 30, 2018·The New England Journal of Medicine·Robert J FoxUNKNOWN NN102/SPRINT-MS Trial Investigators
Dec 5, 2018·Neurological Research·Anne Katrine AndreasenFinn Sellebjerg
Jul 20, 2019·Physiotherapy Theory and Practice·Fatih SokeBilge Gonenli Kocer
Jan 30, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Rohit BakshiUNKNOWN SUMMIT consortium
Jun 12, 2019·International Urogynecology Journal·Denise Cuevas PérezAna Isabel de la Llave Rincón
Jul 8, 2020·Revue neurologique·N EhrléS Bakchine
Feb 13, 2021·Multiple Sclerosis and Related Disorders·Anat AchironTomer Ziv-Baran
Feb 25, 2021·Neurology. Neuroimmunology and Neuroinflammation·Rebekka RustFriedemann Paul
Apr 9, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·C ChengC Power
Jul 22, 2021·Annals of Clinical and Translational Neurology·Timothy J SchultzJanakan Ravindran
Sep 23, 2021·European Journal of Physical and Rehabilitation Medicine·Rocco S CalabròUNKNOWN Italian Consensus Conference on Robotics in Neurorehabilitation (CICERONE)

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