On the origin of epileptic High Frequency Oscillations observed on clinical electrodes

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
M ShamasFabrice Wendling

Abstract

In this study we aim to identify the key (patho)physiological mechanisms and biophysical factors which impact the observability and spectral features of High Frequency Oscillations (HFOs). In order to accurately replicate HFOs we developed virtual-brain/virtual-electrode simulation environment combining novel neurophysiological models of neuronal populations with biophysical models for the source/sensor relationship. Both (patho)physiological mechanisms (synaptic transmission, depolarizing GABAA effect, hyperexcitability) and physical factors (geometry of extended cortical sources, size and position of electrodes) were taken into account. Simulated HFOs were compared to real HFOs extracted from intracerebral recordings of 2 patients. Our results revealed that HFO pathological activity is being generated by feed-forward activation of cortical interneurons that produce fast depolarizing GABAergic post-synaptic potentials (PSPs) onto pyramidal cells. Out of phase patterns of depolarizing GABAergic PSPs explained the shape, entropy and spatiotemporal features of real human HFOs. The terminology "high-frequency oscillation" (HFO) might be misleading as the fast ripple component (200-600 Hz) is more likely a "high-frequency activity"...Continue Reading

Citations

Aug 28, 2019·The European Journal of Neuroscience·Jurgen HebbinkHil G E Meijer
Apr 21, 2020·Journal of Computational Neuroscience·Yves DenoyerPascal Benquet
Apr 20, 2019·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sijin RenWilliam C Stacey
Apr 14, 2021·Journal of Neural Engineering·Mariam Al HarrachFabrice Wendling
Sep 17, 2021·Journal of Mathematical Neuroscience·Elif Köksal Ersöz, Fabrice Wendling

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