On the origin of low-frequency blood pressure variability in the conscious dog

The Journal of Physiology
A JustP B Persson

Abstract

1. Baroreceptor denervation increases blood pressure variability below 0.1 Hz. This study was undertaken to determine to what extent these fluctuations originate from the central nervous system or from cardiovascular sources. 2. Blood pressure was recorded at a rate of 10 Hz for approximately 3.5 h in conscious, resting dogs. Power density spectra were calculated from all 2(17) points of each recording session and integrated between 0.0002 and 0.1 Hz. 3. Blockade of the afferent limb of the baroreceptor reflex by surgical denervation of sinoaortic and cardiopulmonary afferents (Den; n = 6) significantly increased integrated power more than sixfold compared with a control group (n = 11). 4. Impairment of the efferent limb in non-deafferented dogs by either alpha 1-adrenergic blockade with prazosin (Praz; n = 7) or ganglionic blockade with hexamethonium (Hex; n = 6) failed to raise variability. 5. Both prazosin (n = 6) and hexamethonium (n = 3) reduced the increased variability in denervated dogs. 6. In non-deafferented dogs receiving hexamethonium, elevation of mean blood pressure to the hypertensive level of the Den group, by a continuous infusion of noradrenaline (n = 4), did not change the variability. 7. It is concluded that...Continue Reading

Citations

Nov 15, 1997·The American Journal of Physiology·P B Persson
Oct 11, 2001·Journal of Hypertension·P B PerssonG Parati
Jul 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·David R BrownDavid C Randall
Aug 9, 2020·Frontiers in Neuroscience·Michael G Z Ghali, George Z Ghali
Sep 14, 1999·The American Journal of Physiology·D E BurgessD R Brown
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A JustH Ehmke
May 8, 1999·The American Journal of Physiology·S C MalpasP C Austin

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