On the origin of the chordate central nervous system: expression of onecut in the sea urchin embryo

Evolution & Development
Albert PoustkaGeorgia Panopoulou

Abstract

We identified a transcription factor of the onecut class in the sea urchin Strongylocentrotus purpuratus that represents an ortholog of the mammalian gene HNF6, the founding member of the onecut class of proteins. The isolated sea urchin gene, named SpOnecut, encodes a protein of 483 amino acids with one cut domain and a homeodomain. Phylogenetic analysis clearly places the sea urchin gene into this family, most closely related to the ascidian onecut gene HNF-6. Nevertheless, phylogenetic analysis reveals a difficult phylogeny indicating that certain members of the family evolve more rapidly than others and also that the cut domain and homeodomain evolve at a different pace. In fly, worm, ascidian, and teleost fish, the onecut genes isolated so far are exclusively expressed in cells of the central nervous system (CNS), whereas in mammals the two copies of the gene have acquired additional functions in liver and pancreas development. In the sea urchin embryo, expression is first detected in the emerging ciliary band at the late blastula stage. During the gastrula stage, expression is limited to the ciliary band. In the early pluteus stage, SpOnecut is expressed at the apical organ and the elongating arms but continues most promi...Continue Reading

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Citations

Aug 11, 2011·Development·Lynne M AngererRobert D Burke
Jun 19, 2013·Current Opinion in Genetics & Development·M Dolores MolinaThierry Lepage
Sep 12, 2007·Evolution & Development·Maria ByrneRobert D Burke
Aug 11, 2011·The Journal of Comparative Neurology·Fuguo WuXiuqian Mu
Aug 17, 2010·Developmental Biology·Shunsuke YaguchiRobert D Burke
Apr 1, 2014·Developmental Biology·Maria Rosa PezzottiMargherita Branno
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Apr 25, 2009·Developmental Biology·Cynthia A BradhamAlbert J Poustka
Apr 25, 2017·Ecotoxicology and Environmental Safety·Nadia RuoccoMaria Costantini
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Mar 7, 2021·Biology·Irene DeiddaNadia Lampiasi
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Feb 7, 2015·Development·Julius C BarsiEric H Davidson
Feb 20, 2015·The Journal of Experimental Biology·Linda Z Holland
Mar 8, 2014·Genome Research·Julius C BarsiEric H Davidson

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