On the physical-chemical effect of colostral antibody binding to Escherichia coli O 86

Immunological Communications
L EdeboC Tagesson

Abstract

Sensitization of Escherichia coli O 86 with colostrum or purified colostral sIgA antibody produces a physical-chemical change of the bacterial surface detectable as a change in partition in dextran-polyethylene glycol polymer two-phase systems. Sensitization with colostrum or sIgA reduces affinity for the dextran-rich phase. In contrast immune serum, IgG and complement increase the affinity for that phase. The results are compatible with the hypothesis that hydrophilic particles, e.g. certain strains of bacteria, are less liable to attachment to and phagocytosis by animal cells than hydrophobic particles, e.g. other bacterial strains. Sensitization with secretory IgA enhances the hydrophilicity thereby making possible an escape mechanism operating at the mucosal surfaces.

References

Jul 21, 1973·Lancet·B TaylorJ F Soothill
Aug 28, 1969·The New England Journal of Medicine·R H Buckley, S C Dees
Mar 1, 1974·The Journal of Infectious Diseases·S Shedlofsky, R Freter
Jan 1, 1974·Immunological Communications·C J van OssJ R Border
Jan 1, 1973·Proceedings of the Society for Experimental Biology and Medicine·A ZipurskyJ Bienenstock
Dec 1, 1973·Clinical Allergy·J F Soothill
Jan 1, 1965·The Journal of Experimental Medicine·T B TOMASIR A PRENDERGAST

Citations

Apr 1, 1978·Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology·K E MagnussonL Edebo
Oct 1, 1977·Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology·L PerersC Tagesson
Jan 1, 1980·Scandinavian Journal of Infectious Diseases. Supplementum

Related Concepts

Blood Group H Type 1 Antigen
Binding Sites, Antibody
Colostrum
Saviosol
Erythrocytes
Alkalescens-Dispar Group
IgA2
Colostral IgA
Phagocytosis
Vigilon

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