On the physiological and cellular homeostasis of ascorbate.

Cellular & Molecular Biology Letters
Magdalena Przybyło, Marek Langner

Abstract

Recent interest in the role of ascorbate in crucial metabolic processes is driven by the growing number of medical reports that show beneficial effects of ascorbate supplementation for maintaining general well-being and recovery from a variety of medical conditions. The effect of ascorbate on the local body environment highly depends on its local concentration; at low concentrations it can cause the reduction of reactive oxygen and facilitate activities of enzymes, while at high concentrations it generates free radicals by reducing ferric ions. Ascorbate serving as an electron donor assists the iron-containing proteins and the iron transfer between various aqueous compartments. These functions require effective and adjustable mechanisms responsible for ascorbate biodistribution. In the paper we propose a new biophysical model of ascorbate redistribution between various aqueous body compartments. It combines recent experimental evidence regarding the ability of ascorbate to cross the lipid bilayer by unassisted diffusion, with active transport by well-characterized sodium vitamin C transporter (SVCT) membrane proteins. In the model, the intracellular concentration of ascorbate is maintained by the balance of two opposing fluxes:...Continue Reading

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Citations

Dec 9, 2020·Antioxidants·Marco B MorelliGaetano Santulli
Nov 13, 2020·Toxicology Research·Denisse Calderón-VallejoJ Luis Quintanar
Nov 14, 2020·Inorganic Chemistry·D Chase PectolMarcetta Y Darensbourg

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