PMID: 490215Oct 1, 1979Paper

On the physiological basis of vitamin A-stimulated growth

The Journal of Nutrition
M H ZileH F DeLuca

Abstract

The influence of vitamin A depletion on tissue composition was studied in rats that were marginally vitamin A deficient, i.e. at their weight plateau stage. The total number of cells (DNA) was decreased in most organs as a result of vitamin A depletion. In thymus, spleen and the sublingual glands there was also a dramatic reduction in the number of cells per gram of tissue and in thymus and sublingual glands there was an increase in the protein to DNA ratio as a result of absence of dietary.vitamin A. We present the hypothesis that vitamin A stimulates growth by a direct role in cell replication in addition to or instead of stimulating the differentiation of epithelial and bone cells.

Citations

Nov 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·D I Thurnham
Apr 1, 1988·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R O OreffoA Z Zallone
Jan 1, 1995·American Journal of Human Biology : the Official Journal of the Human Biology Council·Mark Skinner
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·E M McDowellM Huang
Sep 1, 1983·Calcified Tissue International·D P DeSimone, A H Reddi
Aug 17, 2000·The Journal of Infectious Diseases·D I ThurnhamP G Lunn

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