PMID: 8584425Jan 1, 1996Paper

On the possible origin of giant or slow-rising miniature end-plate potentials at the neuromuscular junction

Pflügers Archiv : European journal of physiology
L C SellinS Thesleff

Abstract

Giant or slow-rising miniature end-plate potentials (GMEPPs) caused by vesicular release of acetylcholine (ACh) occur at any time in about 50% of mouse diaphragm neuro muscular junctions, but generally at frequencies less than 0.03 s-1. Their frequency is, unlike that of miniature end-plate potentials (MEPPs), not affected by nerve terminal depolarization. Unlike MEPPs and stimulus-evoked end-plate potentials, GMEPPs have a prolonged time-to-peak and show an increase in time-to-peak with amplitude. By using these differences in amplitude and time course, GMEPPs can be separated from MEPPs. In contrast to MEPPs, GMEPPs are not blocked by botulinum neurotoxin type A. GMEPPs have a greater temperature sensitivity than MEPPs, disappearing at temperatures below 15 degrees C. Long-term paralysis by botulinum toxin and certain drugs which inhibit protein kinase C or affect actin filament polymerization (cytochalasins) enhance the frequency of GMEPPs. End-plate current recordings show that similar postsynaptic ACh receptors are activated by MEPPs and GMEPPs. It is suggested that GMEPPs are not caused by mechanisms involved in regulated neurotransmitter release but are generated by constitutive secretion.

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Citations

Apr 4, 2000·Physiological Reviews·G SchiavoC Montecucco
Oct 27, 2004·Basic & Clinical Pharmacology & Toxicology·Yoko Oshima-FrancoLéa Rodrigues-Simioni
Dec 22, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kirat K ChandPeter G Noakes
Jul 2, 2008·The Journal of Physiology·Xueyong WangKathrin L Engisch
Jan 5, 2002·Journal of Physiology, Paris·Frédéric A MeunierJordi Molgó

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