PMID: 1542Dec 29, 1975

On the possible role of organic melanoidin polymers as matrices for prebiotic activity

Journal of Molecular Evolution
A NissenbaumJ Oró

Abstract

One of the major diagenetic pathways of organic matter in recent sediments involves the condensation of cellular constituents, particularly amino acids and sugars, into insoluble melanoidin-type polymers. These polymers consist mainly of humic and fulvic acids and make up the major part of the organic carbon reservoir in recent sediments. We suggest that a similar set of reactions between abiotically formed amino acids and sugars, and more generally between aldehydes and amines, occurred on a large scale in the prebiotic hydrosphere. The rapid formation of this insoluble polymeric material would have removed the bulk of the dissolved organic carbon from the primitive oceans and would thus have prevented the formation of an "organic soup". Melanoidin polymers have several properties which make them attractive hypothetical precursors of contemporary oxidation-reduction coenzymes: 1. they contain heterocyclic nitrogen compounds similar to the nitrogenous bases; 2. they contain a high concentration of stable free radicals; and 3. they tend to concentrate those heavy metals which play prominent roles in contemporary enzymic redox processes. The prebiotic formation of similar polymers could, therefore, have provided the starting poin...Continue Reading

References

Jan 1, 1975·Origins of Life·M Halmann
Aug 1, 1975·Experimental Parasitology·H L Asch, C P Read
Jan 1, 1975·Origins of Life·D M Anderson, A Banin
Apr 18, 1972·British Dental Journal·M A Ford, F M Rimini
Oct 1, 1972·The British Journal of Venereal Diseases·N M Ovcinnikov, V V Delektorskij
Dec 1, 1973·Currents in Modern Biology·A W SchwartzG J Chittenden
Mar 17, 1972·Science·E J Carpenter, K L Smith
Sep 1, 1970·Journal of Agricultural and Food Chemistry·A V Clark, S R Tannenbaum
Jan 1, 1959·Advances in Carbohydrate Chemistry·G P ELLIS
Oct 1, 1971·Science·A C LasagaM J Dwyer

Citations

Dec 1, 1976·Origins of Life·A Nissenbaum
Sep 1, 1981·Origins of Life·W Stillwell, A Rau
Jan 1, 1982·Journal of Molecular Evolution·N Lahav, S Chang
Jan 1, 1981·Bio Systems·G J Chittenden, A W Schwartz
Apr 5, 2014·Astrobiology·Michael J RussellIsik Kanik
Dec 1, 1981·Origins of Life·A Bar-NunJ Oró
Oct 1, 1983·Cryobiology·J L Mansell, J S Clegg
Feb 17, 2005·Experimental and Molecular Pathology·W John Martin, Jon Stoneburner
Jun 30, 2012·Chemical Society Reviews·H James CleavesRobert Hazen

Related Concepts

Aldehydes
Amines
Benzopyrans
Sugars
Chemistry, Organic
Free Radicals
Heterocyclic Compounds
Humic Substances
Hydrogen-Ion Concentration
Iron

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