PMID: 7361569Feb 1, 1980

On the possible role of potassium ions in the action of terbutaline on skeletal muscle contractions

Acta Pharmacologica Et Toxicologica
E Holmberg, B Waldeck

Abstract

The soleus, a slow-contracting, and the extensor digitorum longus (EDL), a fast-contracting muscle from guinea-pig were prepared for isometric recording in vitro, and the effect of terbutaline, a beta-adrenoceptor agonist, was studied during various experimental conditions. In the soleus terbutaline caused an initial depression of the force of contraction followed by an increase. The degree of fusion of subtetanic contractions was reduced throughout the experiment. The EDL responded with an increased force only. The force of contraction of the two muscles increased with the K+-ion concentration of the medium up to 6 mM. Higher concentrations of K+ caused a depression which was partly prevented by terbutaline. When the contractions of the soleus muscle had been depressed by excess K+, depletion of K+ or by ouabain, terbutaline restored the twitch tension. It is suggested that the contractile machinery of the muscles is controlled by the ionic balance which in turn is changed following beta-adrenoceptor stimulation.

References

Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Holmberg, B Waldeck
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Citations

Oct 1, 1982·Acta Pharmacologica Et Toxicologica·P AnderssonB Waldeck
Aug 1, 1997·The American Journal of Physiology·Simeon P CairnsDenis S Loiselle
Oct 27, 2007·Journal of Applied Physiology·Michael J McKennaJean-Marc Renaud
Jul 26, 2011·Sports Medicine·Maren S FragalaJeff S Volek
Jul 22, 2015·Medicine and Science in Sports and Exercise·Anders KalsenJens Bangsbo
Sep 8, 1998·Journal of Applied Physiology·F LaghiM J Tobin
Sep 25, 2003·Physiological Reviews·Torben Clausen
Jun 11, 2002·American Journal of Physiology. Cell Physiology·Craig YensenJean-Marc Renaud
Sep 25, 2015·The Journal of Physiology·Simeon P Cairns, Fabio Borrani
Sep 9, 2006·Journal of Applied Physiology·Duncan N FrenchCarl M Maresh
Aug 15, 2019·American Journal of Physiology. Cell Physiology·Katja K PedersenKristian Overgaard

Related Concepts

Drug Augmentation
Cavia porcellus
Inotropism
Ouabain
Potassium
Terbutalin von ct

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