On the possible role of stimulation duration for after-effects of transcranial alternating current stimulation

Frontiers in Cellular Neuroscience
Daniel StrüberChristoph S Herrmann

Abstract

Transcranial alternating current stimulation is a novel method that allows application of sinusoidal currents to modulate brain oscillations and cognitive processes. Studies in humans have demonstrated transcranial alternating current stimulation (tACS) after-effects following stimulation durations in the range of minutes. However, such after-effects are absent in animal studies using much shorter stimulation protocols in the range of seconds. Thus, stimulation duration might be a critical parameter for after-effects to occur. To test this hypothesis, we repeated a recent human tACS experiment with a short duration. We applied alpha tACS intermittently for 1 s duration while keeping other parameters identical. The results demonstrate that this very short intermittent protocol did not produce after-effects on amplitude or phase of the electroencephalogram. Since synaptic plasticity has been suggested as a possible mechanism for after-effects, our results indicate that a stimulation duration of 1 s is too short to induce synaptic plasticity. Future studies in animals are required that use extended stimulation durations to reveal the neuronal underpinnings. A better understanding of the mechanisms of tACS after-effects is crucial ...Continue Reading

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Citations

Jun 1, 2016·Neural Plasticity·Andrea Antal, Christoph S Herrmann
Mar 26, 2016·Frontiers in Cellular Neuroscience·Kai HeimrathTino Zaehle
Jun 3, 2016·Frontiers in Human Neuroscience·Florian H KastenChristoph S Herrmann
Mar 31, 2016·PLoS Biology·Sankaraleengam AlagapanFlavio Frӧhlich
Feb 8, 2019·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Yuranny Cabral-Calderin, Melanie Wilke
Nov 30, 2019·ELife·Yuqi DengBarbara G Shinn-Cunningham
Feb 16, 2017·Frontiers in Human Neuroscience·Florian H Kasten, Christoph S Herrmann
Jul 25, 2017·Frontiers in Psychology·Stefano GallottoTom A de Graaf
Mar 14, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Juliann M MellinFlavio Fröhlich
Mar 3, 2020·Frontiers in Aging Neuroscience·Shane FresnozaAnja Ischebeck
Jun 12, 2018·Frontiers in Human Neuroscience·Johannes VosskuhlChristoph S Herrmann
Sep 12, 2017·Frontiers in Human Neuroscience·Christopher GundlachBernhard Sehm
Feb 15, 2021·Brain Research·Aline M DantasTeresa Schuhmann
Jun 5, 2021·Brain Communications·Beatrice P De KoninckLouis De Beaumont
Jun 8, 2021·Journal of Healthcare Engineering·Aiping LiuMartin J McKeown
Jul 27, 2021·Frontiers in Human Neuroscience·Mária Orendáčová, Eugen Kvašňák
Jun 26, 2021·NeuroImage·Roberto F Salamanca-GironFriedhelm C Hummel

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