PMID: 6969880Nov 1, 1980Paper

On the postsynaptic action of glutamate in frog spinal motoneurons

Pflügers Archiv : European journal of physiology
U Sonnhof, C P Bührle

Abstract

In the isolated frog spinal cord depolarization of motoneurons (MNs) induced by glutamate (GLUT) was not accompanied by measurable changes of neuronal input resistance when chemical synaptic transmission was blocked by Mn2+ or Mg2+. The GLUT depolarization was, however, paralleled by a considerable increase in K+ in the extracellular space. To clarify, whether the GLUT depolarization was exclusively due to a reduction of the transmembrane K+ gradient or whether ion conductances not detectable by measurements of neuronal input resistance were involved, membrane potential (MP) was plotted semilogarithmically versus extracellular K+ activity (aKe+). During experimental elevation of aKe+ the function delta MP/dec. delta aKe+ was found to agree fairly with the Nernst equation. The slope of this function was much steeper during GLUT superfusion, indicating an influx of positive ions. The elevation of aKe+ during the GLUT action can mimic postsynaptic effects by release of transmitter from presynaptic terminals synapsing with the recorded cell. In vivo preparations do not allow blockade of chemical synaptic transmission. Therefore, it is impossible to decide, whether the recorded cell is depolarized either postsynaptically by GLUT or ...Continue Reading

References

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Citations

Jan 1, 1982·Pflügers Archiv : European journal of physiology·U SonnhofH Kettenmann
Feb 1, 1983·Pflügers Archiv : European journal of physiology·C P Bührle, U Sonnhof
Jan 1, 1983·Progress in Biophysics and Molecular Biology·E Syková
Dec 1, 1981·Brain Research·E Puil
Jan 1, 1981·Progress in Neurobiology·J W Phillis, P H Wu
Dec 13, 1982·Neuroscience Letters·J C HackmanR A Davidoff
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D X ZhangR A Davidoff
Mar 1, 1984·The Annals of Otology, Rhinology, and Laryngology·C DechesneA Sans

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