On the potential role of intestinal microbial community in hepatocarcinogenesis in chronic hepatitis B

Cancer Medicine
Ashraf Mohamadkhani

Abstract

The chronic infection of hepatitis B virus (HBV) is the most potent risk factor for the development of cirrhosis and hepatocellular carcinoma (HCC). The association of intestinal microbiota alteration with progressive liver disease has been investigated in recent studies. Overgrowth of potentially pathogenic bacteria of gram-negative species and, in particular, a significant increase in the fecal count of Escherichia coli (E. coli) are characterized in the presence of HCC. This study was conducted to describe the characteristics of the intestinal microbiota related to the presence of HCC in HBV-carrier patients. The available literature indicates the colonization of E. coli as principal source of portal vein lipopolysaccharide (LPS), in the gut may contribute to the carcinogenesis process by inducing chronic inflammation. This understanding could help to predict the clinical outcomes in HBV-carrier patients and innovative strategies to reduce the virulence of liver disease from intestinal dysbiosis.

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Citations

Feb 10, 2020·Environmental Science and Pollution Research International·Yijie YangLihong Chai
Oct 23, 2019·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Rashi SehgalNirupma Trehanpati
Jan 17, 2021·Biology·Mohammed El-MowafyWalid Mottawea
Oct 11, 2020·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Mar 7, 2021·Antioxidants·Mariapia VairettiClarissa Berardo
Jul 3, 2021·International Journal of Molecular Sciences·Norihisa NishimuraHitoshi Yoshiji
Jul 27, 2021·World Journal of Clinical Cases·Gulsum Ozlem Elpek

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