On the prediction of simultaneous inbreeding coefficients at multiple loci

Genetical Research
Jules Hernández-SánchezJohn A Woolliams

Abstract

A new deterministic method for predicting simultaneous inbreeding coefficients at three and four loci is presented. The method involves calculating the conditional probability of IBD (identical by descent) at one locus given IBD at other loci, and multiplying this probability by the prior probability of the latter loci being simultaneously IBD. The conditional probability is obtained applying a novel regression model, and the prior probability from the theory of digenic measures of Weir and Cockerham. The model was validated for a finite monoecious population mating at random, with a constant effective population size, and with or without selfing, and also for an infinite population with a constant intermediate proportion of selfing. We assumed discrete generations. Deterministic predictions were very accurate when compared with simulation results, and robust to alternative forms of implementation. These simultaneous inbreeding coefficients were more sensitive to changes in effective population size than in marker spacing. Extensions to predict simultaneous inbreeding coefficients at more than four loci are now possible.

Citations

Dec 15, 2010·Genetics Research·Xin-Sheng Hu, Zhiquan Wang
May 29, 2008·Annual Review of Genomics and Human Genetics·B S Weir
May 18, 2007·Genetics·William G Hill, Jules Hernández-Sánchez

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