On the primary site of control in the spontaneous development of small-intestinal sucrase-isomaltase after birth

FEBS Letters
G SebastioG Semenza

Abstract

We have compared the appearance in the small intestine of baby rabbits, of sucrase and isomaltase activities and of the sucrase-isomaltase mRNA. For the latter we used a cDNA probe encompassing approximately 4.1 kb from the 5'-end of pro-sucrase-isomaltase cDNA [(1986) Cell 46, 227-234]. Sucrase-isomaltase mRNA and the enzyme activities developed simultaneously from the 15th day after birth onwards. Over two orders of magnitude the enzymatic activities and sucrase-isomaltase mRNA matched one another closely, thus ruling out translation as the main site of biosynthetic control during spontaneous development, while rendering very probable transcription as the primary site of control. However, we cannot rule out the possibility that, prior to day 15, sucrase-isomaltase mRNA might be degraded so rapidly that it is not translated.

References

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Citations

Dec 1, 1990·Digestive Diseases and Sciences·P GeorgesN Romain
Nov 30, 1995·Molecular and Cellular Endocrinology·C C TsengM M Wolfe
Oct 1, 1996·Journal of Pediatric Gastroenterology and Nutrition·E N EmvoC Foltzer-Jourdainne
Dec 16, 1987·Biochemical and Biophysical Research Communications·G SebastioG Semenza
Aug 15, 2000·Annual Review of Nutrition·I R Sanderson, S Naik
Jul 31, 1987·Biochemical and Biophysical Research Communications·G SebastioE Boncinelli
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Related Concepts

Age Factors
Metazoa
Exoglycosidases
Intestines, Small
Exo-Oligo-1,6-Glucosidase
Chinchilla Rabbits
Poly(A) Tail
Mutansucrase
Transcription, Genetic

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