PMID: 2501501May 1, 1989Paper

On the rate of DNA sequence evolution in Drosophila

Journal of Molecular Evolution
P M Sharp, W H Li

Abstract

Analysis of the rate of nucleotide substitution at silent sites in Drosophila genes reveals three main points. First, the silent rate varies (by a factor of two) among nuclear genes; it is inversely related to the degree of codon usage bias, and so selection among synonymous codons appears to constrain the rate of silent substitution in some genes. Second, mitochondrial genes may have evolved only as fast as nuclear genes with weak codon usage bias (and two times faster than nuclear genes with high codon usage bias); this is quite different from the situation in mammals where mitochondrial genes evolve approximately 5-10 times faster than nuclear genes. Third, the absolute rate of substitution at silent sites in nuclear genes in Drosophila is about three times higher than the average silent rate in mammals.

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Citations

Dec 1, 1992·Journal of Molecular Evolution·G Marfany, R Gonzàlez-Duarte
Jun 1, 1995·Journal of Molecular Evolution·J M Hancock
Mar 1, 1990·Journal of Molecular Evolution·A Caccone, J R Powell
Mar 1, 1990·Journal of Molecular Evolution·S D WermanR J Britten
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Jun 1, 1991·Journal of Molecular Evolution·G Marfany, R Gonzàlez-Duarte
Nov 1, 1990·Journal of Molecular Evolution·J R Thackeray, C P Kyriacou
May 23, 1996·Molecular & General Genetics : MGG·A Domínguez, J Albornoz
Oct 8, 1997·Journal of Molecular Evolution·E N Moriyama, J R Powell
Jul 9, 2009·Molecular Genetics and Genomics : MGG·Newton Medeiros VidalElgion Lucio Silva Loreto
May 23, 2012·Molecular Genetics and Genomics : MGG·Elgion L S LoretoLizandra J Robe
Mar 3, 2007·Biochemical Genetics·Wilma V Colón-Parrilla, Ivette Pérez-Chiesa
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