PMID: 6986011Jan 1, 1980Paper

On the relation of glucose and insulin secretion in the fasting state

Metabolism: Clinical and Experimental
H G Joost, J Beckmann

Abstract

In the isolated perfused rat pancreas the relationship between glucose concentration and insulin release was altered by fasting for 1-3 days. The maximum effect decreased progressively, while there was no change in the glucose concentration, yielding half of maximum response. Prolonged perfusion of the pancreas from fasting rats with glucose (20 mM) failed to restore the reduced secretion. The insulin content of the pancreas gland decreased after the second day of starvation. Blood glucose, however, was unchanged for 4 days after an initial fall. It is concluded that the capacity of the secretory mechanism, rather than its sensitivity to glucose, is reduced by starvation.

References

Jul 1, 1978·Metabolism: Clinical and Experimental·U LilavivathanaR G Brodows
Jan 1, 1973·Acta Endocrinologica·D S Turner, D A Young
Feb 1, 1969·Metabolism: Clinical and Experimental·K D BuchananR H Williams
May 1, 1970·The Journal of Clinical Investigation·N J GreyD M Kipnis
Nov 1, 1966·The Journal of Clinical Investigation·G F CahillD M Kipnis

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Citations

Dec 1, 1990·Molecular and Chemical Neuropathology·G Kaur, K Kaur
Jan 1, 1982·Comparative Biochemistry and Physiology. A, Comparative Physiology·J CodinaE Herrera
Jul 1, 1985·The Journal of Clinical Investigation·O Björkman, L S Eriksson
Aug 21, 2001·Biological & Pharmaceutical Bulletin·T MaedaM Miwa
Jun 1, 1983·Metabolism: Clinical and Experimental·C A Longano, H P Fletcher
Jun 9, 2016·Journal of Animal Physiology and Animal Nutrition·P M N JoslinS J Swoap
Sep 1, 1983·The American Journal of Physiology·L PenicaudJ Le Magnen

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