On the relationship between microbubble fragmentation, deflation and broadband superharmonic signal production

Ultrasound in Medicine & Biology
Brooks D LindseyP Dayton

Abstract

Acoustic angiography imaging of microbubble contrast agents uses the superharmonic energy produced from excited microbubbles and enables high-contrast, high-resolution imaging. However, the exact mechanism by which broadband harmonic energy is produced is not fully understood. To elucidate the role of microbubble shell fragmentation in superharmonic signal production, simultaneous optical and acoustic measurements were performed on individual microbubbles at transmit frequencies from 1.75 to 3.75 MHz and pressures near the shell fragmentation threshold for microbubbles of varying diameter. High-amplitude, broadband superharmonic signals were produced with shell fragmentation, whereas weaker signals (approximately 25% of peak amplitude) were observed in the presence of shrinking bubbles. Furthermore, when populations of stationary microbubbles were imaged with a dual-frequency ultrasound imaging system, a sharper decline in image intensity with respect to frame number was observed for 1-μm bubbles than for 4-μm bubbles. Finally, in a study of two rodents, increasing frame rate from 4 to 7 Hz resulted in decreases in mean steady-state image intensity of 27% at 1000 kPa and 29% at 1300 kPa. Although the existence of superharmonic ...Continue Reading

References

Sep 1, 1991·The Journal of the Acoustical Society of America·S I MadanshettyR E Apfel
Jan 1, 1997·Ultrasound in Medicine & Biology·E C EverbachR S Meltzer
May 20, 1998·Ultrasound in Medicine & Biology·P M ShankarV L Newhouse
Sep 15, 1999·Ultrasonic Imaging·W T ShiB B Goldberg
Feb 25, 2000·Ultrasound in Medicine & Biology·W T Shi, F Forsberg
May 23, 2001·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·P P ChangL A Crum
May 23, 2001·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·J E ChomasK W Ferrara
May 29, 2001·Journal of Biomedical Optics·J E ChomasK Ferrara
Jul 13, 2002·Ultrasound in Medicine & Biology·Wen Shiang ChenLawrence A Crum
Feb 1, 2003·The Journal of the Acoustical Society of America·Wen-Shiang ChenLawrence A Crum
May 17, 2003·Ultrasound in Medicine & Biology·Ayache BouakazNico De Jong
Mar 8, 2005·Ultrasound in Medicine & Biology·Ayache BouakazNico de Jong
May 4, 2005·Breast Cancer Research and Treatment·Yasushi NakamuraKennichi Kakudo
Oct 26, 2005·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Dustin E Kruse, Katherine W Ferrara
Jan 21, 2006·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Mark A BordenKatherine W Ferrara
Feb 14, 2006·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Azzdine Y AmmiWilliam D O'Brien
Jun 7, 2006·Applied Physics Letters·Shukui ZhaoPaul A Dayton
Mar 23, 2007·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Elena BiagiLeonardo Masotti
May 25, 2007·Ultrasound in Medicine & Biology·David E GoertzAntonius F W van der Steen
Jun 21, 2007·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·C C CoussiosR A Roy
Aug 4, 2007·The Journal of the Acoustical Society of America·Charles F CaskeyKatherine W Ferrara
Aug 28, 2007·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Hendrik J VosPiero Tortoli
Oct 13, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S E DuffG C Jayson
Dec 21, 2007·AJR. American Journal of Roentgenology·Tae Kyoung KimStephanie R Wilson
Feb 2, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·P A DaytonK W Ferrara
Feb 2, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·K E MorganK W Ferrara
Mar 18, 2008·Ultrasound in Medicine & Biology·Chih-Kuang Yeh, Shin-Yuan Su
Apr 2, 2008·Ultrasound in Medicine & Biology·Saurabh DattaChristy K Holland
Sep 16, 2008·Ultrasonics·Alexander A DoinikovPaul A Dayton
Oct 11, 2008·Ultrasound in Medicine & Biology·D H ThomasV Sboros
Oct 28, 2008·Journal of Colloid and Interface Science·Jameel A FeshitanMark A Borden
Feb 12, 2009·The Journal of the Acoustical Society of America·Jeroen SijlMichel Versluis
Aug 25, 2009·Ultrasound in Medicine & Biology·Olivier CoutureMickael Tanter
Sep 11, 2009·The Journal of the Acoustical Society of America·Kyuichi YasuiYasuo Iida
Dec 31, 2009·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Francesco GuidiPiero Tortoli
Jan 14, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·James J Kwan, Mark A Borden
Jun 17, 2010·The Journal of the Acoustical Society of America·Daniel A KingWilliam D O'Brien
Aug 4, 2010·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Ryan GessnerPaul A Dayton
Aug 21, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Debra J Cox, James L Thomas
Sep 30, 2010·Physics in Medicine and Biology·Yao-Sheng TungElisa E Konofagou
Jul 12, 2012·The Journal of the Acoustical Society of America·Kevin J HaworthChristy K Holland
Dec 19, 2012·Ultrasound in Medicine & Biology·Debra J Cox, James L Thomas
Mar 12, 2013·Ultrasound in Medicine & Biology·Jonathan CaseyRobert J Eckersley
Apr 4, 2013·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Francois VignonThomas R Porter

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Citations

Mar 31, 2015·Ultrasound in Medicine & Biology·Brooks D LindseyPaul A Dayton
May 11, 2016·Ultrasonics·Brooks D LindseyPaul A Dayton
Oct 25, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Zhuochen WangXiaoning Jiang
May 11, 2017·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Brooks D LindseyXiaoning Jiang
Mar 7, 2018·Abdominal Radiology·Wui K ChongPaul A Dayton
Nov 5, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Helen MulvanaEleanor Stride
Aug 30, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Anna L EmanuelEtto C Eringa
Nov 5, 2016·Physics in Medicine and Biology·Jason L RaymondChristy K Holland
Aug 16, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Brooks D LindseyPaul A Dayton
Dec 3, 2020·The Journal of the Acoustical Society of America·Krit Sujarittam, James J Choi
Jul 25, 2020·Ultrasound in Medicine & Biology·Isabel G Newsome, Paul A Dayton
Apr 6, 2021·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yuxue WangXiang Liu
Apr 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yi-Ju HoChih-Kuang Yeh
Jul 17, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Ronald L HallShashank R Sirsi

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