On the release of transmitter at normal, myasthenia gravis and myasthenic syndrome affected human end-plates

The Journal of Physiology
S G Cull-CandyO D Uchitel

Abstract

1. Transmitter release has been studied at normal, myasthenia gravis (m.g.) and myasthenic syndrome (m.s.) affected human end-plates. At normal and diseased end-plates evoked transmitter release is Poisson for a mean quantal content, m less than ten. 2. The relation between log m and log [Ca]o, at normal and m.g. end-plates is linear, with a slope of 3.3-3.4. The value of m at m.g. end-plates is about five times larger than normal, below Ca 0.7 mM (Mg, 2mM). This difference in m is reduced at higher Ca levels. 3. The slope of the relation between log m.e.p.p. frequency and log [K]o is similar at normal and m.g. end-plates. Over its linear portion the relationship has a slope of approximately 6. 4. Fluctuations in the latency of evoked transmitter release were compared at normal and m.g. nerve terminals. At normal end-plates the probability of release reaches a peak about 0.3-0.4 msec after unitary e.p.p.s of the shortest latency and returns to zero about 1.0 msec after the peak. At m.g. end-plates the distribution of latencies shows less uniformity. 5. At m.s. end-plates m is approximately 5 in normal Ringer solution (2 mM-Ca, 1 mM-Mg). The relation between log m and log [Ca]o is linear, with a slope of 1.0-1.5. The K dependenc...Continue Reading

Citations

Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sitt Wai FongGuy S Bewick
Mar 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Francisco J UrbanoRichard W Tsien
Feb 1, 1997·Disease-a-month : DM·R Pourmand
Dec 1, 1991·Journal of Neurocytology·P R Lyons, C R Slater
May 6, 1998·Current Opinion in Neurobiology·G W Davis, C S Goodman
Jan 1, 1985·European Archives of Psychiatry and Neurological Sciences·H LundhI Rosén
Oct 1, 1993·Acta Anaesthesiologica Scandinavica·K H ChanC Y Lin
Dec 1, 1994·Muscle & Nerve·J BurgesD Wray
May 13, 1999·The American Journal of Medicine·K BoonyapisitR L Ruff
Aug 6, 2008·Journal of Neuroimmunology·Francisco J UrbanoOsvaldo D Uchitel
Feb 3, 2007·Trends in Neurosciences·Mark M Rich, Peter Wenner
Jun 15, 2010·Muscle & Nerve·Erik H NiksJaap J Plomp
Nov 1, 1994·Survey of Ophthalmology·D A WeinbergT L Vollmer
Sep 1, 1983·Current Problems in Cancer·A M SpenceR Ruff
Jul 1, 1989·Acta Anaesthesiologica Scandinavica·E NilssonJ Heinonen
Nov 1, 1981·Journal of Neurochemistry·P C MolenaarA Vincent
Sep 1, 1987·Anaesthesia·A P Wainwright, P M Brodrick
Jun 1, 1988·Clinical and Experimental Pharmacology & Physiology·A J HarborneI G Marshall
May 28, 2014·Muscle & Nerve·Ravindra K HajelaWilliam D Atchison
Jul 30, 2014·Neuron·Tingting WangGraeme W Davis
Mar 16, 2001·The Tohoku Journal of Experimental Medicine·T FukudomeK Eguchi
May 6, 2016·Frontiers in Synaptic Neuroscience·Robert J Kittel, Manfred Heckmann
Aug 26, 1998·Current Biology : CB·L T Landmesser
Nov 12, 2014·Annual Review of Physiology·Graeme W Davis, Martin Müller
Feb 22, 2001·Annual Review of Physiology·G W Davis, I Bezprozvanny
Dec 1, 1987·Brain Research·S Rochel, N Robbins
Jun 1, 2016·Journal of Neurochemistry·Dominique Fernandes, Ana Luísa Carvalho
Jul 29, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·T S Lin, H C Chiu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.