PMID: 36111Jan 1, 1979

On the respiration analeptic effect of fominoben HCl after administration of pethidine/promethazine (author's transl)

S VölpelJ Eichler


The respiratory stimulatory effect of 3'chloro-2'-(N-methyl-N-[(morpholino-carbonyl)methyl]-aminomethyl)benzanilide hydrochloride (fominoben, Noleptan, PB 89) on the respiratory-depressing effect of pethidine/promethazine was investigated. In addition a double blind study was carried out on 36 patients with fominoben or placebo after pethidine/promethazine. To evaluate respiratory function the vital capacity, Tiffeneau-value, volume of inhaled air/s, maximum breathing capacity, as well as the blood gas values (pO2, pCO2 and pH according to Astrup) were measured. The results can be summarised as follows: 1. As was to be expected the combination pethidine/promethazine caused a deterioration in all parameters. This negative effect could be partially improved by fominoben. 2. A marked difference in the volume of inhaled air/s could be seen after fominoben in comparison to the placebo. The remaining differences were insignificant. 3. Pethidine/promethazine had, as had been expected, a significant effect on pain symptoms, but no analgetic effect could be shown for fominoben.

Related Concepts

Meperidine Hydrochloride
Cell Respiration
Respiratory Physiology
Blood Gas
Vital Capacity Test
Drug Interactions
Respiratory Gaseous Exchange in Organisms

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