On the retention of neurotensin in the ventral tegmental area (VTA) despite destruction of the main neurotensinergic afferents of the VTA--implications for the organization of forebrain projections to the VTA

Brain Research
Stefanie Geisler, Daniel S Zahm

Abstract

Neurotensin (NT) modulates ventral tegmental area (VTA) signaling in a manner relevant to psychostimulant drug actions, thus inviting evaluation of psychostimulant effects in conditions of reduced or absent VTA NT. However, in a preliminary study, NT immunoreactivity (-ir) in the VTA was unaffected following destruction of the main concentration of forebrain neurotensinergic VTA afferents in the lateral preoptic-rostral lateral hypothalamic continuum (LPH) and adjacent lateral part of the medial preoptic area (MPOA). This study attempted to determine what measures are necessary to obtain a significant reduction of VTA NT-ir. Large unilateral ibotenic acid lesions were made in several structures containing NTergic, VTA-projecting neurons, including the LPH-MPOA, nucleus accumbens, VTA itself and dorsal raphe. None of these was associated with substantial ipsilateral loss of NT-ir in the VTA, lateral hypothalamus or lateral habenula. Combinations of lesions, such as LPH-MPOA plus VTA and LPH-MPOA plus dorsal raphe, also failed to substantially reduce NT-ir in these structures. Transections of the medial forebrain bundle (mfb) likewise failed to produce a substantial loss of VTA NT-ir measured with immunohistochemistry and radioim...Continue Reading

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Citations

Jan 17, 2009·Reviews in the Neurosciences·Stefanie Geisler, Roy A Wise
May 25, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefanie GeislerDaniel S Zahm
May 19, 2012·The Journal of Comparative Neurology·Huxing CuiMichael Lutter
Apr 11, 2015·Progress in Neurobiology·David H RootT Celeste Napier
Jan 15, 2015·Acta neurochirurgica·Judith Maria AnthoferJuergen Schlaier
Jul 19, 2012·The Journal of Comparative Neurology·David H RootMark O West
Aug 30, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Karl Y Bosque-CorderoCarlos A Jimenez-Rivera

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