On the right side? A longitudinal study of left- versus right-lateralized semantic dementia

Brain : a Journal of Neurology
Fiona KumforOlivier Piguet

Abstract

The typical presentation of semantic dementia is associated with marked, left predominant anterior temporal lobe atrophy and with changes in language. About 30% of individuals, however, present with predominant right anterior temporal lobe atrophy, usually accompanied by behavioural changes and prosopagnosia. Here, we aimed to establish whether these initially distinct clinical presentations evolve into a similar syndrome at the neural and behavioural level. Thirty-one patients who presented with predominant anterior temporal lobe atrophy were included. Based on imaging, patients were categorized as either predominant left (n = 22) or right (n = 9) semantic dementia. Thirty-three Alzheimer's disease patients and 25 healthy controls were included for comparison. Participants completed the Addenbrooke's Cognitive Examination, a Face and Emotion Processing Battery and the Cambridge Behavioural Inventory, and underwent magnetic resonance imaging annually. Longitudinal neuroimaging analyses showed greater right temporal pole atrophy in left semantic dementia than Alzheimer's disease, whereas right semantic dementia showed greater orbitofrontal and left temporal lobe atrophy than Alzheimer's disease. Importantly, direct comparisons b...Continue Reading

References

Dec 1, 1992·Brain : a Journal of Neurology·J R HodgesE Funnell
Dec 1, 1991·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·C HelmstaedterC E Elger
Feb 1, 1994·Neuropsychologia·S Samson, R J Zatorre
Mar 24, 2000·Cerebral Cortex·A BecharaA R Damasio
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Sep 24, 2002·Brain : a Journal of Neurology·Howard J RosenBruce L Miller
May 12, 2004·Brain and Cognition·Edmund T Rolls
Sep 7, 2004·Annals of Neurology·John R HodgesGlenda M Halliday
Sep 24, 2004·Dementia and Geriatric Cognitive Disorders·I Lavenu, F Pasquier
Nov 24, 2004·Neurology·S JoubertM Poncet
Apr 27, 2005·Neurology·W W SeeleyH J Rosen
Jul 8, 2005·Brain : a Journal of Neurology·R Rhys DaviesJohn H Xuereb
Sep 16, 2006·International Journal of Geriatric Psychiatry·Eneida MioshiJohn R Hodges
Mar 14, 2007·NeuroImage·Simona M BrambatiMaria Luisa Gorno-Tempini
Mar 22, 2007·Dementia and Geriatric Cognitive Disorders·Christopher M KippsJohn R Hodges
Mar 30, 2007·Brain : a Journal of Neurology·Ingrid R OlsonYoussef Ezzyat
Sep 12, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·C WedderburnC Williams-Gray
Sep 12, 2007·Annals of the New York Academy of Sciences·Indre V ViskontasBruce L Miller
Nov 21, 2007·Nature Reviews. Neuroscience·Karalyn PattersonTimothy T Rogers
Mar 20, 2009·Brain : a Journal of Neurology·Dennis ChanNick C Fox
Sep 19, 2009·Brain : a Journal of Neurology·Jennifer L WhitwellKeith A Josephs
Jul 20, 2010·NeuroImage·Martin ReuterBruce Fischl
Oct 19, 2010·Brain : a Journal of Neurology·Marco MionPeter J Nestor
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Mar 8, 2011·NeuroImage·Martin Reuter, Bruce Fischl
Jun 29, 2011·Journal of Molecular Neuroscience : MN·Phillip D Fletcher, Jason D Warren
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Aug 23, 2011·Brain : a Journal of Neurology·Sharpley HsiehJohn R Hodges
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
Oct 12, 2012·Social Cognitive and Affective Neuroscience·Ingrid R OlsonLars A Ross
Nov 6, 2012·NeuroImage·Jorge L Bernal-RusielUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Feb 8, 2013·Neurology·Cristian E LeytonJohn R Hodges
Mar 8, 2013·Dementia and Geriatric Cognitive Disorders·Sharon SavageJohn R Hodges
May 8, 2013·Brain : a Journal of Neurology·Rebecca J Von Der HeideIngrid R Olson

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Citations

Apr 4, 2016·NeuroImage·Kristian TylénRiccardo Fusaroli
Jun 18, 2017·Nature Reviews. Neurology·Lieke H MeeterJohn C van Swieten
Feb 3, 2018·Brain : a Journal of Neurology·Fiona KumforOlivier Piguet
Dec 1, 2017·Neurodegenerative Disease Management·Ramon Landin-Romero, Olivier Piguet
Feb 3, 2018·Journal of Neurology·Charles R MarshallJason D Warren
Nov 27, 2018·Journal of the History of the Neurosciences·Guido Gainotti
Feb 2, 2019·Continuum : Lifelong Learning in Neurology·Hugo Botha, Keith A Josephs
Jan 30, 2019·Current Opinion in Neurology·Boon Lead Tee, Maria Luisa Gorno-Tempini
Oct 19, 2017·Journal of the International Neuropsychological Society : JINS·Christa L WatsonMaria Luisa Gorno-Tempini
Dec 5, 2017·Journal of the International Neuropsychological Society : JINS·Skye McDonald
Jul 16, 2019·Journal of Clinical and Experimental Neuropsychology·Catherine MerckSolène Kalénine
Jun 25, 2016·Journal of Alzheimer's Disease : JAD·Tim Van LangenhoveJohn R Hodges
Jun 9, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Justin MironUNKNOWN PREVENT-AD research group
Apr 17, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Rebekah M Ahmed, John R Hodges
Jun 5, 2020·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Mario F MendezOleg Yerstein
Feb 13, 2020·Current Opinion in Neurology·Olivier Piguet, Fiona Kumfor
Aug 21, 2019·Neuropsychology Review·Yu ChenOlivier Piguet
Aug 25, 2020·Brain : a Journal of Neurology·Hulya Ulugut ErkoyunYolande Pijnenburg
Mar 18, 2020·Brain Imaging and Behavior·Francesca CasoMassimo Filippi
Jun 20, 2018·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Grace E RiceMatthew A Lambon Ralph
Aug 9, 2018·Frontiers in Neurology·Soumia BenbrikaBéatrice Desgranges
Nov 30, 2018·Cognitive, Affective & Behavioral Neuroscience·Fiona KumforOlivier Piguet
Dec 6, 2016·Alzheimer's Research & Therapy·Ramon Landin-RomeroFiona Kumfor
Mar 6, 2018·Journal of Alzheimer's Disease : JAD·John R Hodges, Olivier Piguet
Sep 7, 2018·Frontiers in Neurology·Maxime MontembeaultRaffaella Migliaccio
Mar 30, 2020·Alzheimer's Research & Therapy·Martina BocchettaJonathan D Rohrer
Jul 12, 2020·Journal of Alzheimer's Disease : JAD·Simon SchwabMatthias Grieder
May 22, 2020·Brain : a Journal of Neurology·Alexander G MurleyJames B Rowe
Jan 12, 2019·Aging Clinical and Experimental Research·Carlo AbbateMatteo Cesari
Nov 23, 2020·Brain : a Journal of Neurology·Maxime BertouxMickaël Laisney

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