On the Role of Cortex-Basal Ganglia Interactions for Category Learning: A Neurocomputational Approach

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Francesc VillagrasaFred H Hamker

Abstract

In addition to the prefrontal cortex (PFC), the basal ganglia (BG) have been increasingly often reported to play a fundamental role in category learning, but the circuit mechanisms mediating their interaction remain to be explored. We developed a novel neurocomputational model of category learning that particularly addresses the BG-PFC interplay. We propose that the BG bias PFC activity by removing the inhibition of cortico-thalamo-cortical loop and thereby provide a teaching signal to guide the acquisition of category representations in the corticocortical associations to the PFC. Our model replicates key behavioral and physiological data of macaque monkey learning a prototype distortion task from Antzoulatos and Miller (2011) Our simulations allowed us to gain a deeper insight into the observed drop of category selectivity in striatal neurons seen in the experimental data and in the model. The simulation results and a new analysis of the experimental data based on the model's predictions show that the drop in category selectivity of the striatum emerges as the variability of responses in the striatum rises when confronting the BG with an increasingly larger number of stimuli to be classified. The neurocomputational model ther...Continue Reading

Citations

Apr 3, 2020·The European Journal of Neuroscience·Javier Baladron, Fred H Hamker
Mar 3, 2019·Trends in Cognitive Sciences·Angela RadulescuIan Ballard
Apr 23, 2021·Nature·Sandra ReinertPieter M Goltstein
Jul 28, 2021·Neural Networks : the Official Journal of the International Neural Network Society·Oliver MaithFred H Hamker

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Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

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