On the role of defects and surface chemistry for surface-assisted laser desorption ionization from silicon

The Journal of Chemical Physics
Sergey AlimpievSergey Nikiforov

Abstract

The generation of ions from silicon substrates in surface-assisted laser desorption ionization (SALDI) has been studied using silicon substrates prepared and etched by a variety of different methods. The different substrates were compared with respect to their ability to generate peptide mass spectra using standard liquid sample deposition. The desorption/ionization processes were studied using gas-phase analyte deposition. Mass spectra were obtained from compounds with gas-phase basicities above 850 kJmol and with molecular weights up to 370 Da. UV, VIS, and IR lasers were used for desorption. Ionization efficiencies were measured as a function of laser fluence and accumulated laser irradiance dose. Solvent vapors were added to the ion source and shown to result in fundamental laser-induced chemical and physical changes to the substrate surfaces. It is demonstrated that both the chemical properties of the substrate surface and the presence of a highly disordered structure with a high concentration of "dangling bonds" or deep gap states are required for efficient ion generation. In particular, amorphous silicon is shown to be an excellent SALDI substrate with ionization efficiencies as high as 1%, while hydrogen-passivated amor...Continue Reading

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Citations

Aug 24, 2010·Analytical and Bioanalytical Chemistry·K P Law, James R Larkin
Feb 24, 2012·Journal of the American Society for Mass Spectrometry·Shin Hye KimSang Yun Han
May 20, 2008·Journal of the American Society for Mass Spectrometry·Chun-Yuan LoYu-Chie Chen
Oct 18, 2008·Journal of the American Society for Mass Spectrometry·Qiang LiuLin He
Jun 30, 2009·Journal of the American Society for Mass Spectrometry·Ville JokinenMarc Baumann
Apr 3, 2014·Analytical and Bioanalytical Chemistry·Alexander GrechnikovAlexander Makarov
Dec 16, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ryuichi Arakawa, Hideya Kawasaki
Mar 15, 2012·Physical Chemistry Chemical Physics : PCCP·Jessica A StoleeAkos Vertes
Sep 13, 2012·Physical Chemistry Chemical Physics : PCCP·Gennady E KotkovskiyIgor Nabiev
Jul 1, 2009·Journal of Mass Spectrometry : JMS·I V ShmigolV A Pokrovsky
Jun 11, 2009·Mass Spectrometry Reviews·Tiina SikanenRaimo A Ketola
Aug 10, 2012·Analytical Chemistry·Casey R McAlpinRyan M Richards
Jan 17, 2013·Analytical Chemistry·Joanna NiziołTomasz Ruman
Jan 21, 2017·ACS Applied Materials & Interfaces·Meysam KeshavarzKrishnan Venkatakrishnan
Apr 4, 2017·Nanomaterials·Rosaria Anna PiccaFrancesco Palmisano
Jan 12, 2017·Rapid Communications in Mass Spectrometry : RCM·Reshma SinghD Jed Harrison
Aug 5, 2018·Rapid Communications in Mass Spectrometry : RCM·Yasuhide NaitoTakayuki Ohmura
Jul 14, 2010·Rapid Communications in Mass Spectrometry : RCM·Abebaw B JemereD Jed Harrison
Aug 4, 2010·Chemistry : a European Journal·Hideya KawasakiRyuichi Arakawa
Dec 15, 2010·Rapid Communications in Mass Spectrometry : RCM·Sergey AlimpievSergey Nikiforov
Oct 4, 2012·Advanced Materials·Angelina Yimei LimYin Chiang Freddy Boey
Jul 21, 2009·Biochemical Society Transactions·Tony L MerriganRobert W McCullough
Apr 6, 2021·European Journal of Mass Spectrometry·Alexander A GrechnikovSergey M Nikiforov
Jan 14, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Gaëlle PiretRabah Boukherroub
Apr 24, 2010·Analytical Chemistry·Rachel D LoweNicolas H Voelcker

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Methods Mentioned

BETA
irradiating
atomic force microscopy
scanning electron microscopy
AFM
electron paramagnetic resonance

Software Mentioned

SLIM
DIOS
GAMESS

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