On the role of dihydrotestosterone in regulating luteinizing hormone secretion in man

The Journal of Clinical Endocrinology and Metabolism
G SchaisonI Mowszowicz

Abstract

The effect of dihydrotestosterone [17 beta-hydroxy-5 alpha-androstone-3-one (DHT) in the negative regulation of LH was studied throughout 3 months of percutaneous administration of this steroid to six normal male volunteers and six patients with primary testicular hypogonadism. In addition, testosterone (T) was administered according to the same protocol to the six hypogonadal patients. Plasma T, DHT, estradiol, sex hormone-binding globulin, and LH levels were measured by RIA before and weekly during treatment. In normal men, plasma DHT rose regularly from 0.5 +/- 0.2 to 3.3 +/- 0.9 ng/ml after 3 months of treatment. Concurrently, T decreased from 5.5 +/- 2.0 to 2.9 +/- 0.3 ng/ml, and sex hormone-binding globulin levels decreased from 1.2 +/- 0.1 to 0.9 +/- 0.05 mg/liter. Mean basal LH levels remained stable between 1.9 +/- 1.3 and 3.1 +/- 1.1 mIU MRC, LH 68/40 per ml throughout treatment. In hypogonadal men after DHT treatment, basal LH levels were not suppressed. In contrast, after T administration, plasma LH decreased from 19.8 +/- 5.4 mIU/ml to normal levels (3.4 +/- 2.7 mIU/ml). From these studies, we conclude that 1) high levels of plasma DHT, maintained over a long period, were unable to lower plasma LH in either normal ...Continue Reading

Citations

May 20, 1999·Baillière's Clinical Endocrinology and Metabolism·R S Swerdloff, C Wang
Jul 17, 1998·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·F SattlerR Horton
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·A S BhatnagarK Schieweck
Jul 29, 1998·The Journal of Urology·L R MillerP C Walsh
Aug 10, 2005·Expert Opinion on Pharmacotherapy·Ammar QoubaitaryChristina Wang
Apr 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Christina Wang, Ronald S Swerdloff
Aug 1, 1993·The Journal of Urology·S K ChoiB de Lignieres
Oct 14, 2020·Brain and Behavior·Nishit SawalSatinder Gombar

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