On the Role of Fibrocytes and the Extracellular Matrix in the Physiology and Pathophysiology of the Spiral Ligament

Frontiers in Neurology
Noa PeelemanVincent Van Rompaey

Abstract

The spiral ligament in the cochlea has been suggested to play a significant role in the pathophysiology of different etiologies of strial hearing loss. Spiral ligament fibrocytes (SLFs), the main cell type in the lateral wall, are crucial in maintaining the endocochlear potential and regulating blood flow. SLF dysfunction can therefore cause cochlear dysfunction and thus hearing impairment. Recent studies have highlighted the role of SLFs in the immune response of the cochlea. In contrast to sensory cells in the inner ear, SLFs (more specifically type III fibrocytes) have also demonstrated the ability to regenerate after different types of trauma such as drug toxicity and noise. SLFs are responsible for producing proteins, such as collagen and cochlin, that create an adequate extracellular matrix to thrive in. Any dysfunction of SLFs or structural changes to the extracellular matrix can significantly impact hearing function. However, SLFs may prove useful in restoring hearing by their potential to regenerate cells in the spiral ligament.

References

Dec 1, 1979·Hearing Research·T KonishiP E Hamrick
Jan 1, 1992·Acta Oto-laryngologica·N B SlepeckyT J Yoo
Aug 1, 1994·Hearing Research·H S LiB J Morley
Jan 1, 1993·Connective Tissue Research·I Thalmann
Jan 1, 1993·The Annals of Otology, Rhinology, and Laryngology·H F Schuknecht, M R Gacek
Feb 19, 2002·Mechanisms of Development·Brigitte MalgrangePhilippe P Lefebvre
Oct 17, 2002·Journal of the Association for Research in Otolaryngology : JARO·Yong WangM Charles Liberman
Oct 3, 2003·The Tohoku Journal of Experimental Medicine·Zhen-Hua JinToshimitsu Kobayashi
Dec 12, 2003·Brain Research. Molecular Brain Research·Tsumoru TerunumaAkira Hara
Dec 24, 2003·Journal of the Association for Research in Otolaryngology : JARO·Keiko Hirose, M Charles Liberman
Jan 24, 2006·Experimental Gerontology·Daniela BuckiovaJosef Syka
Mar 16, 2006·The Journal of Comparative Neurology·Hainan LangBradley A Schulte
May 25, 2006·Acta Oto-laryngologica·Sung-Kyun MoonDavid J Lim
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Moo-Jin BaekVincent K Tuohy
Sep 12, 2006·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Hanqi ChuYonghua Cui
Sep 23, 2006·Physiology·Hiroshi Hibino, Yoshihisa Kurachi
Oct 21, 2006·Nature Reviews. Neuroscience·Matthew W Kelley
Jun 19, 2007·Acta Oto-laryngologica·Masaomi MoriyamaMasashi Suzuki
Jun 27, 2007·The American Journal of Pathology·Kazusaku KamiyaTatsuo Matsunaga
Jan 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Fumiaki NinYoshihisa Kurachi
Jun 27, 2008·Cell and Tissue Research·Ying-Peng Liu, Hong-Bo Zhao
Mar 12, 2009·Journal of the Association for Research in Otolaryngology : JARO·Joe C Adams
Feb 25, 2010·European Journal of Human Genetics : EJHG·Kristien P HoornaertGeert R Mortier
Dec 15, 2010·Biochemical and Biophysical Research Communications·Mee Hyun SongJinwoong Bok
Jan 20, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Yong CuiKaoru Ogawa
Jun 16, 2011·PloS One·Min Dai, Xiaorui Shi
Aug 23, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Min DaiXiaorui Shi
Apr 27, 2012·Journal of Neuroscience Research·Guang-Wei SunTatsuo Matsunaga
Jun 13, 2012·Proceedings of the National Academy of Sciences of the United States of America·Wenjing ZhangXiaorui Shi
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Dennis R Trune, Barbara Canlon
Jan 11, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne-Cécile BoulayMartine Cohen-Salmon
Apr 9, 2013·International Journal of Pediatric Otorhinolaryngology·Hiromi KasagiHidetake Kurihara
Jun 7, 2013·Journal of the Association for Research in Otolaryngology : JARO·Judy R DubnoRichard A Schmiedt

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.