On the role of modeling parameters in IMRT plan optimization

Physics in Medicine and Biology
Michael KrauseChristian Thieke

Abstract

The formulation of optimization problems in intensity-modulated radiotherapy (IMRT) planning comprises the choice of various values such as function-specific parameters or constraint bounds. In current inverse planning programs that yield a single treatment plan for each optimization, it is often unclear how strongly these modeling parameters affect the resulting plan. This work investigates the mathematical concepts of elasticity and sensitivity to deal with this problem. An artificial planning case with a horse-shoe formed target with different opening angles surrounding a circular risk structure is studied. As evaluation functions the generalized equivalent uniform dose (EUD) and the average underdosage below and average overdosage beyond certain dose thresholds are used. A single IMRT plan is calculated for an exemplary parameter configuration. The elasticity and sensitivity of each parameter are then calculated without re-optimization, and the results are numerically verified. The results show the following. (1) elasticity can quantify the influence of a modeling parameter on the optimization result in terms of how strongly the objective function value varies under modifications of the parameter value. It also can describe...Continue Reading

References

Oct 16, 2002·International Journal of Radiation Oncology, Biology, Physics·Margie A HuntClifton C Ling
Nov 1, 2002·Physics in Medicine and Biology·M AlberF Nüsslin
Nov 16, 2002·Physics in Medicine and Biology·Beong Choi, Joseph O Deasy
Jun 25, 2004·Physics in Medicine and Biology·H Edwin RomeijnJonathan G Li
Apr 1, 2006·The Lancet Oncology
Mar 31, 2007·International Journal of Radiation Oncology, Biology, Physics·David CraftThomas Bortfeld

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Citations

Dec 3, 2014·Mathematical Biosciences·Anna HoffmannKarl-Heinz Küfer
Feb 28, 2016·BMC Cancer·Hope MurphyHana M Dobrovolny

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