On the role of quantitative brain imaging in the differential diagnosis of speech disorders

Psychiatry and Clinical Neurosciences
Ludger H Tebartz van ElstMichael Hüll

Abstract

We present the case of a 71-year-old woman with an 11-year history of slowly progressive decline of motor speech. Normal clinical investigations including routine magnetic resonance imaging (MRI) at 7, 8 and 10 years after the onset of speech dysfunction led to the suggestion of a psychogenic disorder. Extensive clinical, neuropsychological and neuroimaging investigations including 18F-desoxyglucose-positron emission tomography (PET), quantitative MRI and MR spectroscopy were performed to look for subtle brain pathology. Quantitative assessment of 3D-MRI, F-desoxyglucose-PET and magnetic resonance spectroscopy all demonstrated clear evidence of multifocal frontotemporal brain pathology that had not been picked up on routine MRI investigations on previous admissions. This is the longest benign history of slowly progressive anarthria reported so far. It demonstrates a possible role of quantitative neuroimaging techniques in the diagnosis of complex neuropsychiatric disorders.

References

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Citations

May 25, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·R GallassiR Lodi
Apr 15, 2006·Brain : a Journal of Neurology·Keith A JosephsRonald C Petersen
Mar 3, 2012·Brain : a Journal of Neurology·Keith A JosephsJennifer L Whitwell
Jan 20, 2012·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Swantje MatthiesLudger Tebartz van Elst
Aug 17, 2019·American Journal of Speech-language Pathology·E Susan DuncanSeyed Ahmad Sajjadi

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