On the role of serotonin and effort in voluntary attention: evidence of genetic variation in N1 modulation

Behavioural Brain Research
Sören EngeAlexander Strobel

Abstract

Ascending serotonergic projections from the raphe nuclei to frontal brain areas and the dense distribution of receptor and transporter sites in prefrontal and sensory regions support the idea that serotonin exerts influence on cognitive functioning. Indeed, growing evidence suggests serotonin to be an important factor in learning and memory; however, its precise role in executive processes particularly in voluntary attention is less clear. Event-related EEG studies showed the N1 potential to predict top-down attention allocation and implicated the auditory N1 in central serotonergic activity. Dipole analyses and single-trial coupling of EEG and fMRI revealed N1 sources in the primary auditory cortex and in the anterior cingulate. In the present study, amplitude variation of the event-related N1 potential was investigated on 72 healthy subjects while performing an auditory novelty oddball paradigm to tap top-down and bottom-up attention allocation. Possible serotonergic effects on voluntary attention were analyzed using allele variants of a functional polymorphism (5-HTTLPR) of the gene encoding the serotonin transporter, a key regulator of serotonergic neurotransmission. Because mental effort has been related to top-down attent...Continue Reading

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Jan 11, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Luis PennanenLaurence H Tecott
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Jun 16, 2018·Neuropsychologia·Holly Sullivan-TooleElizabeth Tricomi
May 25, 2021·Frontiers in Neuroscience·Denise Elfriede Liesa Lockhofen, Christoph Mulert

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