On the role of the immunoproteasome in transplant rejection

Immunogenetics
Michael BaslerMarcus Groettrup

Abstract

The immunoproteasome is expressed in cells of hematopoietic origin and is induced during inflammation by IFN-γ. Targeting the immunoproteasome with selective inhibitors has been shown to be therapeutically effective in pre-clinical models for autoimmune diseases, colitis-associated cancer formation, and transplantation. Immunoproteasome inhibition prevents activation and proliferation of lymphocytes, lowers MHC class I cell surface expression, reduces the expression of cytokines of activated immune cells, and curtails  T helper 1 and 17 cell differentiation. This might explain the in vivo efficacy of immunoproteasome inhibition in different pre-clinical disease models for autoimmunity, cancer, and transplantation. In this review, we summarize the effect of immunoproteasome inhibition in different animal models for transplantation.

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Citations

Sep 6, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael BaslerMarcus Groettrup
Aug 26, 2020·Genes and Immunity·Michael Basler, Marcus Groettrup
Mar 19, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael BaslerMarcus Groettrup

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Methods Mentioned

BETA
amino acid exchange

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