Apr 14, 1976

On the separation of fibrinogen degradation products D and E

Biochimica Et Biophysica Acta
F R Matthias, G Hocke

Abstract

Separation of fibrinogen degradation products D and E by means of gel chromatography cannot be achieved at neutral pH even in the presence of high ionic strength of the elution buffer. It is assumed that fragments D and E are linked together in a complex preventing the separation despite different molecular weights of both components. By means of addition of chaotropic substances like 1 M Kl to the elution buffer clear separation of degradation products D and E on Sephadex G-200 columns can be achieved.

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Mentioned in this Paper

Immunoelectrophoresis
Sephadex G 200
Fibrinogen
Fibrinogen Assay
Plasma Protein Binding Capacity
Gel Chromatography
Electrophoresis, Disc
Peptide Fragments
Fibrinogen Complex Location
Fibrinogen Activity

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