PMID: 7085360Jan 1, 1982Paper

On the significance of alcoholism for etiology, course and prognosis of cancer of the mouth and oropharynx (author's transl)

H J Schultz-Coulon, W Schmidt


Reviewing the records of 131 patients with malign tumors of the mouth and oropharynx 36 (35%) alcoholics were found among 103 male patients with carcinoma. The highest incidence of alcoholism (58%) was seen in patients with carcinoma of the floor of the mouth. In alcoholics the age distribution showed a peak in the 4th decennium, whereas non-alcoholics had this peak in the 6th decennium. With 64% T3-tumors the alcoholics revealed on an average markedly more advanced tumor stages before treatment than the other patient group with only 29% T3-tumors; metastases in the regional lymphnodes were seen in 50% of the latter, but in 72% of the alcoholics. Skin reaction to radiation therapy appeared particulary pronounced more often in alcoholics (87%) than in the other patients (63%). The 3-year survival rates were 38.5% (alcoholics) and 44.5% (non-alcoholics). These observations suggest that alcoholism with its numerous accompaniments does not only play a role in etiology, but does also have unfavourable effects on the course and the prognosis of cancer of the mouth and oropharynx.

Related Concepts

Alcohol Abuse
Buccal Mucosa
Malignant Neoplasm of Mouth
Malignant Neoplasm of Pharynx

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