On the Significance of Systolic Flow Waveform on Aortic Valve Energy Loss

Annals of Biomedical Engineering
Hoda HatoumLakshmi P Dasi

Abstract

This study aims to quantitatively and qualitatively assess energy dissipation in the aortic valve as a function of systolic aortic flow waveform representing pathologies where flow time-to-peak is delayed. A bioprosthetic valve was tested in the aortic position of a left-heart simulator under physiological pressure and flow conditions. The flow loop piston pump was programmed to generate three different flow waveforms each with a different peak time annotated as early peak (EP) with a rapid acceleration, mid peak (MP) and late peak (LP) with a rapid deceleration. Energy dissipation was calculated from flow and pressure measurements while sinus vorticity dynamics were evaluated using time-resolved planar particle image velocimetry. Average pressure gradients during systole are found 30.2 ± 0.19, 30.7 ± 0.25 and 32.9 ± 0.29 mmHg and average dissipation over systole is found 0.95 ± 0.026, 1.05 ± 0.034 and 1.25 ± 0.043 W for EP, MP and LP respectively. As systole's acceleration phase is slower, sinus vortices are more likely to form, necessitating more energy exchange from shear layers inducing more viscous dissipation. EP found in healthy individuals is superior in terms of reducing energy dissipation and increasing aortic valve e...Continue Reading

References

Jul 17, 2004·Annual Review of Biomedical Engineering·Ajit P YoganathanS Casey Jones
Apr 8, 2010·Journal of Biomechanical Engineering·Choon-Hwai YapAjit P Yoganathan
Feb 1, 2015·Annals of Biomedical Engineering·Brandon L Moore, Lakshmi Prasad Dasi
Oct 27, 2015·Journal of Biomechanical Engineering·Ikechukwu U OkaforAjit P Yoganathan
Dec 22, 2015·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Mikael KanskiHåkan Arheden
Oct 30, 2016·Journal of the American Heart Association·Daisuke KamimuraWilliam C Little
Nov 23, 2016·Annals of Biomedical Engineering·Lakshmi P DasiAjit P Yoganathan
Apr 2, 2017·Biomechanics and Modeling in Mechanobiology·Vivek VasudevanChoon Hwai Yap
Apr 24, 2017·The Journal of Thoracic and Cardiovascular Surgery·Hoda HatoumLakshmi Prasad Dasi
Mar 5, 2018·The Annals of Thoracic Surgery·Hoda HatoumLakshmi Prasad Dasi
Jul 3, 2018·The Journal of Thoracic and Cardiovascular Surgery·Hoda HatoumLakshmi P Dasi
Jul 8, 2018·The Journal of Thoracic and Cardiovascular Surgery·Hoda HatoumLakshmi Prasad Dasi
Jul 10, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Hoda HatoumLakshmi Prasad Dasi

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Citations

Sep 14, 2018·Annals of Biomedical Engineering·Hoda Hatoum, Lakshmi P Dasi
May 1, 2019·Annals of Biomedical Engineering·Hoda HatoumLakshmi Prasad Dasi
Feb 14, 2020·Annals of Biomedical Engineering·Hoda HatoumLakshmi Prasad Dasi
Feb 3, 2019·Annals of Biomedical Engineering·Hoda Hatoum, Lakshmi Prasad Dasi
Aug 29, 2018·Annals of Biomedical Engineering·Hoda HatoumLakshmi Prasad Dasi
Dec 4, 2019·Annals of Biomedical Engineering·Hoda HatoumLakshmi Prasad Dasi
Nov 27, 2019·The Journal of Thoracic and Cardiovascular Surgery·Hoda HatoumLakshmi Prasad Dasi
Dec 2, 2019·Journal of the Mechanical Behavior of Biomedical Materials·Hoda HatoumLakshmi Prasad Dasi
Jun 25, 2019·The Journal of Thoracic and Cardiovascular Surgery·Megan HeitkemperLakshmi Prasad Dasi
Dec 4, 2021·Cardiovascular Engineering and Technology·Hoda HatoumLakshmi Prasad Dasi

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