On the Slow Diffusion of Point-of-Care Systems in Therapeutic Drug Monitoring

Frontiers in Bioengineering and Biotechnology
Barbara Sanavio, Silke Krol

Abstract

Recent advancements in point-of-care (PoC) technologies show great transformative promises for personalized preventative and predictive medicine. However, fields like therapeutic drug monitoring (TDM), that first allowed for personalized treatment of patients' disease, still lag behind in the widespread application of PoC devices for monitoring of patients. Surprisingly, very few applications in commonly monitored drugs, such as anti-epileptics, are paving the way for a PoC approach to patient therapy monitoring compared to other fields like intensive care cardiac markers monitoring, glycemic controls in diabetes, or bench-top hematological parameters analysis at the local drug store. Such delay in the development of portable fast clinically effective drug monitoring devices is in our opinion due more to an inertial drag on the pervasiveness of these new devices into the clinical field than a lack of technical capability. At the same time, some very promising technologies failed in the clinical practice for inadequate understanding of the outcome parameters necessary for a relevant technological breakthrough that has superior clinical performance. We hope, by over-viewing both TDM practice and its yet unmet needs and latest adv...Continue Reading

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Citations

Nov 27, 2015·Nanomedicine·Elisa SalvatiSilke Krol
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May 25, 2021·Biosensors & Bioelectronics·Hyeon Ji ParkTae Hyeon Yoo
Aug 26, 2021·Analytical and Bioanalytical Chemistry·Florence Anne CastelliChristophe Junot

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Methods Mentioned

BETA
electrophoresis
chip
pregnancy test
PCA

Software Mentioned

Digital Microfluidic

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