On the slowly rising phase of the sodium gating current in the squid giant axon

Proceedings. Biological Sciences
R D Keynes, F Elinder

Abstract

High-resolution records of the sodium gating current in the squid giant axon demonstrate the existence of a slowly rising phase that is first apparent at pulse potentials slightly below zero, and becomes increasingly pronounced at more positive potentials. At +80 mV the current reaches its peak with a delay of 30 microseconds at 10 degrees C. It is suggested that this current is generated by the first two steps labelled R-->P and P-->A in the S4 units of all four domains of the series-parallel gating system, activating the channel before its opening by the third steps A-->B in domains I, II and III in conjunction with hydration. The kinetics of the slowly rising phase can only be explained by the incorporation of an appropriate degree of voltage-dependent cooperativity between the S4 voltage-sensors for their two initial transitions.

References

Dec 1, 1979·The Journal of General Physiology·C M Armstrong, W F Gilly
Sep 29, 1992·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R D KeynesI C Forster
Mar 1, 1991·The Journal of Membrane Biology·M IchikawaG Matsumoto
Nov 1, 1991·Biophysical Journal·J G Starkus, M D Rayner
Jun 22, 1990·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R D KeynesI C Forster
Apr 1, 1990·Pflügers Archiv : European journal of physiology·H Meves, J A Pohl
Aug 1, 1986·The Journal of Physiology·J M BekkersR D Keynes
Apr 1, 1987·The Journal of General Physiology·J R StimersR E Taylor
Jan 1, 1989·European Biophysics Journal : EBJ·F Conti, W Stühmer
Jun 1, 1983·The Journal of General Physiology·R E Taylor, F Bezanilla
Dec 1, 1994·Quarterly Reviews of Biophysics·R D Keynes
Apr 1, 1994·Biophysical Journal·E StefaniF Bezanilla
Feb 1, 1994·The Journal of General Physiology·W N ZagottaR W Aldrich
Dec 1, 1995·The Journal of General Physiology·B HirschbergJ Patlak
Apr 2, 1998·Proceedings. Biological Sciences·R D Keynes, F Elinder

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Citations

Nov 8, 2008·Cell Biochemistry and Biophysics·Sara I Börjesson, Fredrik Elinder
May 29, 2003·Biophysical Journal·Daniel Sigg, Francisco Bezanilla
Nov 12, 2003·The Journal of General Physiology·Amir BroomandFredrik Elinder
Feb 26, 2004·The Journal of General Physiology·Baron ChandaFrancisco Bezanilla
Jul 30, 2008·The Journal of General Physiology·Fabiana V CamposFrancisco Bezanilla
Jun 1, 2011·The Journal of General Physiology·Sara I Börjesson, Fredrik Elinder
Apr 2, 1998·Proceedings. Biological Sciences·R D Keynes, F Elinder
May 27, 1999·Proceedings. Biological Sciences·R D Keynes, F Elinder
Oct 7, 2004·Biophysical Journal·W Zhou, A L Goldin

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