Jan 1, 1984

On the stereoselective aminoacylation of RNA

Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)
D A Usher, M C Needels


Aminoacylation of the "internal" 2'hydroxyl groups of poly(A) with the imidazolide of racemic DL-leucine resulted in the formation of an enantiomeric excess of the D-ester, whereas aminoacylation with the imidazolide of racemic N-3,5-dinitrobenzoyl-DL-leucine gave an enantiomeric excess of the L-ester. Comparison of these results with those obtained earlier for alanine shows that the larger side chain tends to favor the formation of the D-ester. High resolution proton magnetic resonance spectroscopy was performed on the D- and L-alanyl "internal" 2'-esters of 3'5'-ApA. The resonance of the side chain methyl group of the D-ester is upfield from that of the L-ester, and the separation of the peaks increases with a decrease in temperature.

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Mentioned in this Paper

Adenine Polynucleotides
Evolution, Chemical
Protein Biosynthesis
Nitrobenzoic Acids
Origin of Life

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