PMID: 6967512Aug 1, 1980Paper

On the T cell hyperreactivity of NZB mice against H-2-identical cells. Evidence for primary response characteristics and an increased helper potential

The Journal of Experimental Medicine
B Stockinger, U Botzenhardt

Abstract

Experimental evidence presented in this paper suggests that the T cell hyperreactivity of NZB mice against H-2 identical target cells is a true primary response and not the consequence of an in vivo T cell autoimmune priming event. Based on additional data, we believe an elevated potential of T cell help to be present in NZB mice, which facilitates the observed hyperreactivity F1 hybrids of NZB and normal strains of mice inherited the capacity to hyperreact against H-2 identical cells in an H-2-unrestricted fashion. Because the hybrids tested possess both Qa-1 alleles--Qa-1b and Qa-1a--our experiments either indicate the existence of heterogeneity within the Qa-1b system or of an H-2-unrestricted response against additional target antigens. The T cell hyperreactivity might prove to be a valuable tool in further investigations of the pathomechanism of autoimmune disease.

References

Jul 1, 1976·European Journal of Immunology·E SimpsonP Chandler
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·M J Bevan
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg

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Citations

Dec 1, 1982·The Journal of Experimental Medicine·R SmithR R Rich
Jan 1, 1984·Rheumatology International·J Müller-QuernheimD von Steldern
Jan 1, 1981·Immunological Reviews·A N Theofilopoulos, F J Dixon

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