On the TRAIL to successful cancer therapy? Predicting and counteracting resistance against TRAIL-based therapeutics.

Oncogene
L Y DimbergHeide L Ford

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and agonistic antibodies against TRAIL death receptors (DR) kill tumor cells while causing virtually no damage to normal cells. Several novel drugs targeting TRAIL receptors are currently in clinical trials. However, TRAIL resistance is a common obstacle in TRAIL-based therapy and limits the efficiency of these drugs. In this review article we discuss different mechanisms of TRAIL resistance, and how they can be predicted and therapeutically circumvented. In addition, we provide a brief overview of all TRAIL-based clinical trials conducted so far. It is apparent that although the effects of TRAIL therapy are disappointingly modest overall, a small subset of patients responds very well to TRAIL. We argue that the true potential of targeting TRAIL DRs in cancer can only be reached when we find efficient ways to select for those patients that are most likely to benefit from the treatment. To achieve this, it is crucial to identify biomarkers that can help us predict TRAIL sensitivity.

References

May 31, 1996·The Journal of Biological Chemistry·R M PittiA Ashkenazi
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·H L FordA B Pardee
Apr 21, 1999·Current Opinion in Cell Biology·A Ashkenazi, V M Dixit
Jul 20, 1999·The Journal of Clinical Investigation·A AshkenaziR H Schwall
Mar 29, 2000·Scandinavian Journal of Immunology·O HalaasT Espevik
Apr 3, 2001·Nature Medicine·D LawrenceA Ashkenazi
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Erika CretneyMark J Smyth
Apr 10, 2002·The Journal of Biological Chemistry·Youngsoo KimJohn C Reed
Apr 12, 2002·Oncogene·Simone FuldaKlaus-Michael Debatin
Mar 26, 2003·Seminars in Cancer Biology·Nesrin Ozören, Wafik S El-Deiry
Sep 16, 2004·Molecular and Cellular Biology·M Stacey RicciWafik S El-Deiry
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shi-Jun ZhengYouhai H Chen
Dec 14, 2004·Immunity·Gretchen E DiehlAstar Winoto
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Frank A SinicropeXi Ming Tang
Feb 11, 2005·The Journal of Biological Chemistry·Alexander GolksInna N Lavrik
Apr 30, 2005·Cell Death and Differentiation·M MacFarlaneG M Cohen
May 3, 2005·Cancer Immunology, Immunotherapy : CII·Thomas J Sayers, William J Murphy
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·S RayA Almasan
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadeen ZerafaMark J Smyth
Feb 25, 2006·Nature Reviews. Immunology·Ralph C BuddJürg Tschopp
Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tom M GantenHenning Walczak
May 10, 2006·The Journal of Experimental Medicine·Alexander GolksInna N Lavrik
Apr 4, 2007·The International Journal of Biochemistry & Cell Biology·Christina FalschlehnerHenning Walczak
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony W TolcherRoger B Cohen
Aug 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Henry T LynchPatrick M Lynch
Feb 8, 2008·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F Anthony GrecoJerry Klein
Feb 29, 2008·Yonsei Medical Journal·Jin Kuk Yang

❮ Previous
Next ❯

Citations

Oct 1, 2013·Trends in Molecular Medicine·Daniel W Stuckey, Khalid Shah
Aug 27, 2013·Lancet·Rafael RosellNiki Karachaliou
Sep 10, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniela SchmidChristopher J Scott
Feb 3, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin LiJia-Fu Ji
May 2, 2015·Toxicology and Applied Pharmacology·Alba MotaSonsoles Hortelano
Dec 2, 2015·BioMedicine·Tsing-Fen Ho, Chia-Che Chang
Mar 5, 2016·Cell Death and Differentiation·D de MiguelL Martinez-Lostao
Sep 19, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yumin OhSeulki Lee
Nov 20, 2015·Frontiers in Medicine·Srivatsava Naidu, Michela Garofalo
May 20, 2015·Scientific Reports·Jiahe LiMichael R King
Jul 31, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Toshiyasu KawaharaNorman M Kneteman
Aug 19, 2014·Cell Biochemistry and Function·Guodong WuMingli Sun
Apr 1, 2016·Cancer Biology & Therapy·Filiz SenbabaogluTugba Bagci-Onder
Jun 5, 2014·International Journal of Cancer. Journal International Du Cancer·Min Li-Weber
Jan 22, 2015·International Journal of Cancer. Journal International Du Cancer·Katharina HammerDirk M Nettelbeck
Sep 1, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jyun-Yi LinTsing-Fen Ho
May 11, 2013·Journal of Bioscience and Bioengineering·Chia-Che ChangTsing-Fen Ho
Jul 22, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·M LoiM Ponzoni
Jan 24, 2014·Clinical Science·Ilja StrizAlena Sekerkova
Dec 11, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·John R FosterNorman M Kneteman
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Young-Jun JeonCarlo M Croce
Dec 20, 2014·Cell Biochemistry and Biophysics·Wenchao ZhouDazheng Wu
Apr 5, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Julianne D TwomeyBaolin Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
Andrew ThorburnHeide L Ford
Gynecologic Oncology
Kerri S BevisJ Michael Straughn
Cancer Treatment Reviews
Devalingam MahalingamAfshin Samali
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Meiling LuVincent L Cryns
© 2021 Meta ULC. All rights reserved