On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

Integrative Biology : Quantitative Biosciences From Nano to Macro
Douglas B Kell, Etheresia Pretorius


We have recently highlighted (and added to) the considerable evidence that blood can contain dormant bacteria. By definition, such bacteria may be resuscitated (and thus proliferate). This may occur under conditions that lead to or exacerbate chronic, inflammatory diseases that are normally considered to lack a microbial component. Bacterial cell wall components, such as the endotoxin lipopolysaccharide (LPS) of Gram-negative strains, are well known as potent inflammatory agents, but should normally be cleared. Thus, their continuing production and replenishment from dormant bacterial reservoirs provides an easy explanation for the continuing, low-grade inflammation (and inflammatory cytokine production) that is characteristic of many such diseases. Although experimental conditions and determinants have varied considerably between investigators, we summarise the evidence that in a great many circumstances LPS can play a central role in all of these processes, including in particular cell death processes that permit translocation between the gut, blood and other tissues. Such localised cell death processes might also contribute strongly to the specific diseases of interest. The bacterial requirement for free iron explains the st...Continue Reading


Apr 1, 1977·Applied and Environmental Microbiology·S W WatsonF W Valois
Feb 1, 1977·Infection and Immunity·G J Domingue, J U Schlegel
Apr 1, 1992·Medical Hypotheses·Mark Lyte
Aug 1, 1992·Journal of Cellular Physiology·J R BetheaE N Benveniste
Oct 1, 1991·Antonie van Leeuwenhoek·Douglas B KellHans V Westerhoff
Jan 1, 1992·Life Sciences·Mark Lyte, S Ernst
Mar 1, 1990·American Journal of Public Health·Betsy Foxman
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·Charles A Janeway
Jan 1, 1988·Annual Review of Biochemistry·G M Kishore, D M Shah
Feb 1, 1985·The Journal of Experimental Medicine·L M HangA N Theofilopoulos
Jan 1, 1985·Biosensors·C M Harris, Douglas B Kell
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A Goldbeter, D E Koshland
Jan 1, 1994·The Journal of Experimental Medicine·E HailmanS D Wright
May 1, 1995·The Journal of Infectious Diseases·A H FroonW A Buurman
Apr 1, 1995·The Journal of Urology·G J DomingueL G Human
Jun 1, 1994·Antimicrobial Agents and Chemotherapy·J M PrinsP Speelman
Feb 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E T RietschelFranco E Di Padova
Apr 1, 1993·Immunobiology·J D Baumgartner, M P Glauser
Jul 1, 1993·Neuroreport·Judith Miklossy
Jun 1, 1993·The Journal of Endocrinology·Mark Lyte
Mar 1, 1993·Diagnostic Microbiology and Infectious Disease·R H EngT Ogbara
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·X R WuJ J Medina
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R IkäheimoP H Mäkelä
Jan 1, 1997·Microbiology and Immunology·T KirikaeD C Morrison
May 19, 1997·The Journal of Experimental Medicine·D N Posnett, J Edinger
Nov 14, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R L Jurado
Feb 7, 1998·Infection and Immunity·E J HelmerhorstB J Appelmelk
May 29, 1998·The Journal of Clinical Investigation·N LampingRalf R Schumann
Jul 21, 1998·Annals of the New York Academy of Sciences·Tom Novitsky
Sep 28, 1998·Medical Microbiology and Immunology·Brian J BalinAlan P Hudson
Oct 21, 1998·Trends in Microbiology·L Margulis, M J Chapman
Feb 17, 1999·Journal of Molecular and Cellular Cardiology·K L ComstockR A Sabbadini
Jun 3, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·Ralf R Schumann, Janine Zweigner
Jun 3, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·P FraunbergerD Seidel
Nov 24, 1999·The Journal of Biological Chemistry·Richard L KitchensR S Munford
Dec 10, 1999·Journal of the American College of Cardiology·C J WiedermannJ Willeit
Feb 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·A PoltorakB Beutler
Apr 27, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N S TanJ L Ding
May 29, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B DerkxR McCloskey
Sep 7, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N S TanJ L Ding
Jan 3, 2001·The Journal of Clinical Investigation·Paul P Tak, G S Firestein
Feb 7, 2001·The Journal of Experimental Medicine·Siegfried MorathThomas Hartung
Apr 28, 2001·Journal of Clinical Microbiology·S NikkariDavid A Relman
Jun 22, 2001·Lancet·T S Elliott, P A Lambert
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Fernando OrtegaMarta Cascante
Feb 28, 2002·Molecular and Cellular Neurosciences·David BroughNancy Rothwell
Mar 5, 2002·Clinical and Diagnostic Laboratory Immunology·Reinhard BernerChristine Schütt
Apr 9, 2002·Journal of Chemotherapy·R G Holzheimer
Apr 16, 2002·Science·Polly Matzinger
Jun 5, 2002·Annual Review of Biochemistry·Christian R H Raetz, Chris Whitfield
Jul 13, 2002·The American Journal of Medicine·Betsy Foxman
Jul 18, 2002·Intensive Care Medicine·Philipp M LepperMatthias Trautmann
Sep 13, 2002·Critical Care : the Official Journal of the Critical Care Forum·John C MarshallAnastasia N Derzko
Nov 15, 2002·Nature·Darryl R J Macer
Nov 28, 2002·Journal of Clinical Microbiology·Richard W McLaughlinEddie C S Chan
Dec 20, 2002·Nature·Carl Nathan
Dec 20, 2002·Nature·Jonathan Cohen
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Agustín AlbillosMelchor Alvarez-Mon
Jan 10, 2003·The New England Journal of Medicine·Richard S Hotchkiss, Irene E Karl
Jan 16, 2003·The Journal of Biological Chemistry·Stephen E GirardinPhilippe J Sansonetti
Jan 24, 2003·Infection and Immunity·Paul B EckburgDavid A Relman
Feb 11, 2003·Journal of Neuroimmunology·Scott W BrownKrista Fischer-Stenger
Mar 11, 2003·Critical Care Medicine·Johannes M B PöschlOtwin Linderkamp
Mar 22, 2003·Current Opinion in Cell Biology·John J TysonBela Novak
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyInternational Sepsis Definitions Conference
Apr 12, 2003·Critical Care Medicine·Mitchell M LevySCCM/ESICM/ACCP/ATS/SIS
May 23, 2003·Infection and Immunity·Johannes Hm LevelsSander J H van Deventer
Jun 7, 2003·Science·Stephen E GirardinDana J Philpott
Jul 10, 2003·American Journal of Respiratory and Critical Care Medicine·Djillali AnnaneCUB-Réa Network
Jul 24, 2003·Trends in Microbiology·Curtis B DobsonRuth F Itzhaki
Oct 17, 2003·Advances in Microbial Physiology·Galina V MukamolovaMichael Young
Nov 5, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Klaus FassbenderK Beyreuther
Nov 20, 2003·Critical Care : the Official Journal of the Critical Care Forum·Robert F WilsonJames G Tyburski
Dec 12, 2003·The Journal of Biological Chemistry·Stephanie TraubCorinna Hermann
Dec 13, 2003·Carbohydrate Research·Martine Caroff, Doris Karibian
Jan 1, 2004·Trends in Microbiology·Mark Lyte
Jan 20, 2004·Nature Genetics·Galit LahavUri Alon
Jan 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sheryl S JusticeScott J Hultgren
Mar 12, 2004·Neurobiology of Aging·Christopher S LittleDenah M Appelt
Apr 13, 2004·Oncogene·Teiji Wada, Josef M Penninger
Apr 15, 2004·Infectious Disease Clinics of North America·Paul W Ewald
Apr 23, 2004·Trends in Cell Biology·Neil D Perkins
Jun 3, 2004·Neurobiology of Aging·Ruth F ItzhakiBrian J Balin
Jul 13, 2004·Autoimmunity Reviews·Trevor G Marshall, Frances E Marshall
Aug 18, 2004·American Journal of Perinatology·Carolyn GardellaDavid Eschenbach
Aug 26, 2004·Antimicrobial Agents and Chemotherapy·Vladimir FrecerJ L Ding
Oct 16, 2004·International Clinical Psychopharmacology·Raphael M BonelliHans-Peter Kapfhammer
Oct 28, 2004·Biochemical Society Transactions·David E NelsonM R H White
Nov 6, 2004·Journal of Neuroimmunology·Ruth F Itzhaki, M A Wozniak
Nov 13, 2004·Trends in Microbiology·Mathias ChamaillardGabriel Núñez
Dec 21, 2004·Nature Reviews. Microbiology·Samuel I MillerMartin W Bader
Jan 11, 2005·Lancet·Djillali AnnaneJean-Marc Cavaillon
Feb 8, 2005·Current Opinion in Microbiology·Ivo G Boneca
Feb 16, 2005·Journal of Neuroimmunology·Kristie L EnglerKrista Fischer-Stenger
Feb 22, 2005·Journal of Lipid Research·Eoin FahyEdward A Dennis
Mar 24, 2005·Infection and Immunity·Susan L Fink, Brad T Cookson
Apr 29, 2005·Brain : a Journal of Neurology·Yang LiuKlaus Fassbender
May 17, 2005·Neurobiology of Aging·Judith MiklossyKamel Khalili
Aug 3, 2005·PLoS Medicine·John P A Ioannidis
Sep 17, 2005·Journal of Clinical Nursing·Nicola RingAndrew Watterson
Nov 15, 2005·Mass Spectrometry Reviews·Mirko Glinski, Wolfram Weckwerth
Dec 24, 2005·Critical Care Medicine·Greg S MartinMarc Moss
Jan 31, 2006·Current Opinion in Structural Biology·Andrew L HopkinsJohn P Overington
Feb 16, 2006·Journal of Lipid Research·Christian R H RaetzEdward A Dennis
Feb 17, 2006·Nature Immunology·Jason M BrenchleyDaniel C Douek
Feb 18, 2006·Microbes and Infection·Janine ZweignerJoerg R Weber
Feb 18, 2006·Nature Chemical Biology·Michael A FischbachChristopher T Walsh
Feb 24, 2006·Nature Reviews. Immunology·Warren StroberTomohiro Watanabe
Feb 24, 2006·Annals of Surgery·Mario SchietromaGianfranco Amicucci
May 6, 2006·Trends in Microbiology·Nicholas H KeepBrian Henderson
May 16, 2006·Immunobiology·Sek Tong OngJeak Ling Ding
Jun 8, 2006·Annual Review of Biochemistry·Chris Whitfield
Jul 18, 2006·Nature Reviews. Microbiology·Simon V Avery
Aug 16, 2006·The New England Journal of Medicine·Ganesh SuntharalingamNicki Panoskaltsis
Sep 7, 2006·Journal of Endotoxin Research·M Stephen TrentJessica V Hankins
Sep 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Indira U Mysorekar, Scott J Hultgren
Sep 22, 2006·Systems Biology·A E C IhekwabaDouglas B Kell
Oct 13, 2006·Bioinformatics·Stefan HoopsUrsula Kummer
Oct 20, 2006·The New England Journal of Medicine·James A Russell
Oct 21, 2006·FEMS Immunology and Medical Microbiology·Hervé C GérardAlan P Hudson
Oct 24, 2006·Pharmacogenomics·Jan van der GreefRobert N McBurney
Dec 22, 2006·Nature Reviews. Molecular Cell Biology·Neil D Perkins
Apr 13, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D KumarS Alvarez
Apr 13, 2007·Physiological Reviews·Anthony T BlikslagerJack Odle
Aug 11, 2007·Seminars in Immunopathology·Ivan TattoliStephen E Girardin
Aug 24, 2007·Cellular Microbiology·Susan L Fink, Brad T Cookson
Sep 7, 2007·Microbiology and Molecular Biology Reviews : MMBR·Marcus Miethke, Mohamed A Marahiel
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Patricia Vassallo, Richard G Trohman
Oct 5, 2007·Nature·Michael A FlierlPeter A Ward
Oct 19, 2007·Nature·Peter J TurnbaughJeffrey I Gordon
Oct 24, 2007·Methods in Enzymology·Michael J O WakelamAnthony D Postle
Nov 1, 2007·Nature Reviews. Drug Discovery·Paul D Leeson, Brian Springthorpe
Nov 23, 2007·Biochemical Society Transactions·L Le BourhisStephen E Girardin
Nov 23, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Clarisse Cuaz-PérolinMustapha Rouis
Dec 21, 2007·PLoS Medicine·David A RosenScott J Hultgren
Dec 29, 2007·The Journal of Pathology·S Sriskandan, D M Altmann
Jan 15, 2008·Trends in Microbiology·Primrose P E FreestoneMark Lyte
Jan 24, 2008·Cellular and Molecular Life Sciences : CMLS·J L DingBow Ho
Feb 27, 2008·Journal of Neurovirology·Ruth F ItzhakiM A Wozniak
Feb 29, 2008·Cytokine·Yong-Chen LuPamela S Ohashi
May 20, 2008·Advances in Applied Microbiology·Primrose P E Freestone, Mark Lyte
May 20, 2008·Journal of Alzheimer's Disease : JAD·Brian J BalinAlan P Hudson
May 20, 2008·Journal of Alzheimer's Disease : JAD·Judith Miklossy
May 20, 2008·Journal of Alzheimer's Disease : JAD·Ruth F Itzhaki, M A Wozniak
May 20, 2008·Journal of Alzheimer's Disease : JAD·Nadezda Urosevic, Ralph N Martins
May 20, 2008·Journal of Alzheimer's Disease : JAD·Eugene D Weinberg, Judith Miklossy
Jun 7, 2008·Cellular and Molecular Life Sciences : CMLS·L VerstrepenR Beyaert
Jun 21, 2008·Cell Death and Differentiation·Katherine Labbé, Maya Saleh
Jul 8, 2008·Fish & Shellfish Immunology·P SwainS Dash
Jul 12, 2008·European Journal of Clinical Investigation·B K DhakalM A Mulvey
Jul 18, 2008·Handbook of Clinical Neurology·Judith Miklossy
Aug 1, 2008·Microbiology and Immunology·Kosei MoriyamaHideki Hirakawa
Aug 6, 2008·Journal of the American Chemical Society·Rebecca J AbergelKenneth N Raymond
Aug 16, 2008·Cytokine·Garabet YeretssianMaya Saleh
Sep 27, 2008·Journal of Neuroinflammation·Judith MiklossyPatrick L McGeer
Oct 2, 2008·Kidney International·Mitchell P Fink
Oct 4, 2008·Clinical Chemistry·Tanja VollmerJens Dreier
Oct 7, 2008·Clinical Neuropharmacology·Tsuyoshi MiyaokaJun Horiguchi
Oct 22, 2008·Nature Chemical Biology·Andrew L Hopkins
Oct 28, 2008·Trends in Biotechnology·Matej OresicAntonio Vidal-Puig
Oct 28, 2008·Biochimica Et Biophysica Acta·Christopher T Capaldo, Asma Nusrat
Nov 1, 2008·The American Journal of Pathology·Hiroaki YokoteTakashi Yamamura
Nov 21, 2008·Cancer Science·Shinya Toyokuni
Dec 17, 2008·Behavioural Brain Research·Stefanie L BylerTimothy M Barth
Jan 9, 2009·European Journal of Immunology·David BroughNancy Rothwell
Jan 17, 2009·Nature Reviews. Microbiology·Tessa BergsbakenBrad T Cookson
Feb 3, 2009·Cell Biochemistry and Biophysics·Nathan R Perron, Julia L Brumaghim
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Javier R CasoJuan C Leza
Feb 10, 2009·Apoptosis : an International Journal on Programmed Cell Death·Fabiano Pinheiro da Silva, Victor Nizet
Mar 24, 2009·Annual Review of Immunology·Sivakumar Vallabhapurapu, Michael Karin
Apr 17, 2009·Cardiovascular Diabetology·Omar S Al-AttasAlison L Harte
Apr 28, 2009·Autoimmunity Reviews·Amy D ProalTrevor G Marshall
Apr 28, 2009·Autoimmunity Reviews·Paul J AlbertTrevor G Marshall
May 29, 2009·Pharmacological Reviews·Luke A J O'NeillSarah L Doyle
Jun 13, 2009·Expert Opinion on Drug Metabolism & Toxicology·David A PriceTravis Wager
Jun 13, 2009·Current Pharmaceutical Design·Luis UlloaEdwin A Deitch
Jun 16, 2009·Bone Marrow Transplantation·S Wahlin, P Harper
Aug 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianqiang DingShu Fang Liu
Aug 25, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·D W ReidI L Lamont
Sep 18, 2009·Annals of the New York Academy of Sciences·Greg P BlaneyAmy D Proal
Sep 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erin G Reed-GeaghanGary E Landreth
Sep 29, 2009·Journal of Microbiological Methods·Abdessalam CherkaouiJacques Schrenzel
Oct 10, 2009·Progress in Lipid Research·Xiaoyuan Wang, Peter J Quinn
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javier Ochoa-RepárazLloyd H Kasper
Nov 10, 2009·Autoimmunity Reviews·Alan EbringerClyde Wilson
Nov 18, 2009·Infection and Immunity·Kelsey E Sivick, Harry L T Mobley
Dec 2, 2009·Nature Reviews. Rheumatology·Christian Beyer, David S Pisetsky
Jan 16, 2010·Nature Reviews. Microbiology·Lautaro Diacovich, Jean-Pierre Gorvel
Feb 5, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Ruth F Itzhaki, M A Wozniak
Feb 12, 2010·Journal of the Royal Society, Interface·Robert S Parker, Gilles Clermont
Feb 12, 2010·Journal of Inflammation·Laurence HoareauFranck Festy
Feb 13, 2010·Thrombosis Research·Rienk Nieuwland, Augueste Sturk
Mar 5, 2010·European Journal of Immunology·Oliver KeppGuido Kroemer
Mar 17, 2010·Cellular and Molecular Life Sciences : CMLS·Karina R Bortoluci, Ruslan Medzhitov
Mar 20, 2010·European Journal of Dermatology : EJD·V N Saxena, Jaideep Dogra
Mar 23, 2010·Cell·Osamu Takeuchi, Shizuo Akira
Mar 30, 2010·Trends in Biochemical Sciences·David Moquin, Francis Ka-Ming Chan
Mar 31, 2010·Neuroscience Letters·Ozlem MimanZafer Cetinkaya
Apr 1, 2010·Journal of Inflammation·Alison L HartePhilip G McTernan
Apr 9, 2010·Science Translational Medicine·Nyall R LondonDean Y Li
Jan 1, 2009·Journal of Innate Immunity·Lijian Wang, Bobby J Cherayil
Apr 28, 2010·Annual Review of Nutrition·Marianne Wessling-Resnick
May 21, 2010·Journal of Perinatal Medicine·Daniel B DiGiulioDavid A Relman
May 21, 2010·Journal of Perinatal Medicine·Daniel B DiGiulioDavid A Relman
Jul 2, 2010·Plant Signaling & Behavior·Vladimir Chobot, Franz Hadacek
Jul 2, 2010·Sub-cellular Biochemistry·Xiaoyuan Wang, Peter J Quinn
Jul 2, 2010·Sub-cellular Biochemistry·Jeak Ling Ding, Bow Ho
Jul 3, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Byron C ChuHans J Vogel
Jul 8, 2010·Archives of Dermatological Research·Orly H MunzLionel Fry
Sep 9, 2010·Nature Reviews. Molecular Cell Biology·Peter VandenabeeleGuido Kroemer
Sep 10, 2010·Annual Review of Microbiology·David A Hunstad, Sheryl S Justice
Sep 25, 2010·BMC Neuroscience·Christine J HammondBrian J Balin
Oct 6, 2010·Alzheimer Disease and Associated Disorders·Ozge Yilmaz KusbeciSuleyman Yazar
Oct 22, 2010·The American Journal of Clinical Nutrition·Michael B ZimmermannRichard F Hurrell
Oct 23, 2010·Cellular Microbiology·Manfred NairzGünter Weiss
Oct 28, 2010·JAMA : the Journal of the American Medical Association·Theodore J IwashynaKenneth M Langa
Nov 12, 2010·Critical Care : the Official Journal of the Critical Care Forum·Ferhat MezianiFlorence Toti
Dec 9, 2010·Nature Reviews. Urology·Betsy Foxman
Dec 24, 2010·Therapeutic Advances in Neurological Disorders·M A Wozniak, Ruth F Itzhaki
Jan 5, 2011·Chemistry and Physics of Lipids·Jahangir Md Alam, Masahito Yamazaki
Jan 12, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·In-Su KimDong-Kug Choi
Mar 1, 1995·Trends in Ecology & Evolution·Douglas B KellA Grafen
Feb 1, 2011·Cellular & Molecular Immunology·Amy D ProalTrevor G Marshall
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rochellys Diaz HeijtzSven Pettersson
Feb 5, 2011·BMC Systems Biology·Yunjiao WangMark R Muldoon
Feb 5, 2011·Current Opinion in Structural Biology·Lei XiePhilip E Bourne
Feb 8, 2011·Antioxidants & Redox Signaling·Lena J JohnJörg-Dieter Schulzke
Feb 8, 2011·Nature Reviews. Microbiology·Guy E Thwaites, Vanya Gant
Mar 10, 2011·Annals of Neurology·Javier Ochoa-RepárazLloyd H Kasper
Mar 17, 2011·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Takashi DeguchiTetsuro Matsumoto
Apr 7, 2011·European Journal of Immunology·Joao G MagalhaesStephen E Girardin
Apr 12, 2011·Medical Care·Nicole B GablerRichard L Kravitz
Apr 28, 2011·European Journal of Immunology·Charles A Dinarello
May 11, 2011·Molecular Systems Biology·Eric BatchelorGalit Lahav
May 24, 2011·Parkinson's Disease·Mei Liu, Guoying Bing
Jun 16, 2011·Journal of Women's Health·Stefan HeytensThierry Christiaens
Jun 30, 2011·Proteome Science·Johannes Hm LevelsJoost Cm Meijers
Jul 21, 2011·Nature Immunology·Yinon Ben-Neriah, Michael Karin
Jul 23, 2011·Cellular Immunology·John J Haddad, Nisreen E Abdel-Karim
Jul 30, 2011·Stroke; a Journal of Cerebral Circulation·Chia-Hung ChiangHsin-Bang Leu
Aug 3, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Thomas H FrazierCraig J McClain
Aug 10, 2011·The Journal of Experimental Medicine·Monica GumaMichael Karin
Aug 23, 2011·PloS One·Pascale Blais LecoursDavid Marsolais
Sep 10, 2011·Postgraduate Medicine·Mesut Ogrendik, Nihan Karagoz
Sep 16, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Pentti A Leppäluoto
Sep 22, 2011·Expert Reviews in Molecular Medicine·Judith Miklossy
Oct 1, 2011·Nature Reviews. Drug Discovery·Paul D Leeson, Stephen A St-Gallay
Oct 15, 2011·Stroke; a Journal of Cerebral Circulation·Fan ZhaoGuohua Xi
Oct 28, 2011·Nature·Kerstin BererGurumoorthy Krishnamoorthy
Nov 5, 2011·Medical Hypotheses·Katherine L Molnar-Kimber, Charles T Kimber
Nov 5, 2011·Current Opinion in Genetics & Development·N Q Balaban
Nov 30, 2011·Microbes and Infection·Kathryn P Haley, Eric P Skaar
Nov 30, 2011·The Journal of Cell Biology·Hiroshi AshidaChihiro Sasakawa
Dec 6, 2011·Seminars in Fetal & Neonatal Medicine·Daniel B DiGiulio
Dec 29, 2011·Journal of Theoretical Biology·Yunjiao WangDavid S Broomhead
Jan 10, 2012·Annual Review of Immunology·Kenya Honda, Dan R Littman
Jan 11, 2012·Methods in Enzymology·Michaela Gebauer, Arne Skerra
Jan 20, 2012·Nature Reviews. Cancer·Neil D Perkins
Feb 11, 2012·Acta Neuropathologica·Kerstin Berer, Gurumoorthy Krishnamoorthy
Feb 14, 2012·Disease Models & Mechanisms·Catherine B LawrenceElysse M Knight
Feb 22, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tsuyoshi MiyaokaJun Horiguchi
Mar 8, 2012·Future Microbiology·Ruth F Itzhaki, M A Wozniak
Mar 14, 2012·Biochemistry·Marc A BoudreauShahriar Mobashery
Mar 21, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonas MarschallCDC Prevention Epicenters Program
Mar 23, 2012·Immunological Reviews·Joseph A DiDonatoMichael Karin
Mar 27, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Tatiana F S TeixeiraMaria do Carmo G Peluzio
Mar 27, 2012·Schizophrenia Bulletin·E Fuller TorreyRobert H Yolken
Mar 31, 2012·ISRN Hematology·Lutz KochPeter Ruef
Apr 25, 2012·Wiener klinische Wochenschrift·K GrifD Orth
May 2, 2012·Virulence·Christopher R Lupfer, Thirumala-Devi Kanneganti
May 29, 2012·Cell·Scott J DixonBrent R Stockwell
May 31, 2012·Journal of the American Geriatrics Society·Theodore J IwashynaJeremy M Kahn
Jun 12, 2012·Mediators of Inflammation·Abdullateef A Alzolibani, Khaled Zedan
Jun 13, 2012·World Journal of Gastroenterology : WJG·Yaron Ilan
Jun 16, 2012·Science·Jeremy E PurvisGalit Lahav
Jul 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gayathri SrinivasanMatam Vijay-Kumar
Aug 15, 2012·Immunological Reviews·Daolin TangMichael T Lotze
Aug 18, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B Dridi
Sep 7, 2012·British Journal of Anaesthesia·V L Reid, N R Webster
Sep 12, 2012·Behavioural Brain Research·Joanna K SoczynskaRoger S McIntyre
Sep 13, 2012·Nature Reviews. Neuroscience·John F Cryan, Timothy G Dinan
Sep 13, 2012·Mediators of Inflammation·Brygida Kwiatkowska, Maria Maślińska
Sep 15, 2012·Annual Review of Cell and Developmental Biology·Mohamed Lamkanfi, Vishva M Dixit
Sep 19, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wanyan Deng, Jianping Xie
Sep 27, 2012·Current Opinion in Gastroenterology·Paul ForsytheJohn Bienenstock
Oct 13, 2012·Frontiers in Immunology·Thomas Pradeu, Edwin L Cooper
Oct 16, 2012·Trends in Microbiology·Nichole R KlattJason M Brenchley
Oct 23, 2012·Nutrition Research·Tatiana F S TeixeiraMaria do Carmo G Peluzio
Oct 23, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·N Garrido-MesaJ Gálvez
Oct 24, 2012·Antimicrobial Agents and Chemotherapy·Migla Miskinyte, Isabel Gordo
Nov 6, 2012·Cold Spring Harbor Perspectives in Biology·Francis Ka-Ming Chan
Nov 21, 2012·Annals of the New York Academy of Sciences·Jarrod W JohnsonShahriar Mobashery
Nov 22, 2012·Molecular Systems Biology·Yu TanouchiLingchong You
Dec 12, 2012·Neurochemistry International·Claudia FunkeDouglas B Kell
Dec 12, 2012·Toxicologic Pathology·Gerald W Dorn
Dec 26, 2012·Current Opinion in Chemical Biology·Allyson K SiaKenneth N Raymond
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu
Jan 18, 2013·Mediators of Inflammation·Kazuhito AsanoNaoto Keicho
Jan 29, 2013·Critical Care Medicine·R P DellingerSurviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
Jan 31, 2013·Intensive Care Medicine·R P DellingerSurviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 2, 2013·Current Opinion in Rheumatology·Amy D ProalTrevor G Marshall
Feb 7, 2013·Trends in Neurosciences·Jane A Foster, Karen-Anne McVey Neufeld
Feb 7, 2013·Nature Communications·Teruaki NakatsujiRichard L Gallo
Feb 28, 2013·British Journal of Pharmacology·N Garrido-MesaJ Gálvez
Mar 7, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Evanthia A TsalkidouIoannis Tentes
Mar 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yoshihisa KobayashiHiroshi Nakajima
Mar 20, 2013·Molecular Aspects of Medicine·David E SmithMatthias A Hediger
Apr 5, 2013·PloS One·Gilles Guerrier, Eric D'Ortenzio
Apr 9, 2013·Journal of Cellular and Molecular Medicine·Kyriaki ChatzivasileiouHermann Lang
Apr 10, 2013·Biochimica Et Biophysica Acta·Filip CiesielskiBoyan B Bonev
Apr 12, 2013·Immunologic Research·Amy D ProalInge A Lindseth
Apr 19, 2013·Journal of Innate Immunity·James C Hurley, Steven M Opal
May 10, 2013·The Journal of Biological Chemistry·Ling GuoXiang-An Li
May 18, 2013·Nature Reviews. Immunology·Luke A J O'NeillAndrew G Bowie
May 24, 2013·Microbiology and Molecular Biology Reviews : MMBR·Ferdinand C O LosAdam J Ratner
May 25, 2013·Nature Reviews. Immunology·Eicke LatzAndrea Stutz
May 28, 2013·Current Opinion in Microbiology·Youssef AachouiKatryn J Stacey
May 30, 2013·Reproductive Sciences·Richard W HymanLinda C Giudice
Jun 6, 2013·International Journal of General Medicine·Mesut Ogrendik
Jul 3, 2013·Biochemical Pharmacology·David R Webb
Jul 28, 2013·Science·Nobuhiko KayagakiVishva M Dixit
Aug 13, 2013·Biosensors & Bioelectronics·A P DasS Swain
Aug 22, 2013·Frontiers in Cellular and Infection Microbiology·Rustam I Aminov
Aug 29, 2013·International Journal of Circumpolar Health·Julia D RempelElizabeth A C Sellers
Sep 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Alan Ebringer, Taha Rashid
Sep 10, 2013·Current Opinion in Microbiology·S S Epstein
Sep 12, 2013·Virulence·Mitchell P Fink
Oct 11, 2013·Frontiers in Integrative Neuroscience·Augusto J Montiel-CastroGustavo Pacheco-López
Nov 5, 2013·Journal of Molecular Signaling·Shidrokh ArdestaniPampee P Young
Nov 19, 2013·PloS One·Sten Braesch-AndersenMakiko Kumagai-Braesch
Dec 3, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G LuoA S Ibrahim
Dec 4, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Giles Major, Robin Spiller
Dec 11, 2013·Frontiers in Cellular and Infection Microbiology·Larissa D Cunha, Dario S Zamboni
Dec 12, 2013·Journal of Neuroinflammation·Steven F AbcouwerDavid A Antonetti
Dec 19, 2013·PLoS Pathogens·Migla MiskinyteIsabel Gordo
Dec 21, 2013·Nature·Gilad DoitshWarner C Greene
Dec 25, 2013·PLoS Pathogens·Christopher N LaRock, Brad T Cookson
Dec 29, 2013·Brain, Behavior, and Immunity·Yan Wang, Lloyd H Kasper
Jan 7, 2014·Molecular Neurodegeneration·Leon M TaiMary Jo LaDu
Jan 7, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C L LiuZ Y Sun
Jan 25, 2014·American Journal of Respiratory and Critical Care Medicine·Sachin YendeDerek C Angus
Feb 4, 2014·Infectious Disease Clinics of North America·Betsy Foxman
Feb 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Lisa F StinsonJeffrey A Keelan
Feb 8, 2014·PloS One·Xinlin Chen, Pingyan Chen
Feb 18, 2014·Journal of Neuroimmunology·Teresa TrottaMaria Antonietta Panaro
Feb 20, 2014·Metallomics : Integrated Biometal Science·Douglas B Kell, Etheresia Pretorius
Feb 26, 2014·Trends in Microbiology·Haripriya Sridharan, Jason W Upton
Mar 4, 2014·Trends in Molecular Medicine·John C Marshall
Mar 19, 2014·Trends in Molecular Medicine·Sachin YendeDerek C Angus
Mar 22, 2014·Neuroscience Bulletin·Evan DoreyWandong Zhang
Mar 25, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Angel Vila-CorcolesEPIVAC Research Group
Apr 5, 2014·Expert Opinion on Drug Discovery·Christian LehmannCharles C Caldwell
Apr 10, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Etheresia Pretorius, Douglas B Kell
Apr 18, 2014·Clinical and Experimental Pharmacology & Physiology·Zheng WuXi Lin
Apr 24, 2014·The Journal of Physiology·Giada De PalmaElena F Verdu
Jan 10, 2012·Journal of Chemical Education·Manish SudShankar Subramaniam
May 9, 2014·Future Microbiology·Frances Valencia-Shelton, Michael Loeffelholz
May 14, 2014·Prion·Fozia SaleemDavid S Wishart
May 23, 2014·Science Translational Medicine·Kjersti AagaardJames Versalovic
May 27, 2014·Cell·Mohamed Lamkanfi, Vishva M Dixit
Jun 13, 2014·Gut Microbes·Giada De PalmaPremysl Bercik
Jun 18, 2014·Cardiovascular Research·Alberico Luigi CatapanoGiuseppe Danilo Norata
Jul 6, 2014·Advances in Experimental Medicine and Biology·Mark Lyte
Jul 6, 2014·Advances in Experimental Medicine and Biology·Peter Holzer, Aitak Farzi
Jul 6, 2014·Advances in Experimental Medicine and Biology·Premysl Bercik, Stephen M Collins
Jul 6, 2014·Advances in Experimental Medicine and Biology·Mélanie G Gareau
Jul 12, 2014·Journal of Perinatal Medicine·José Luis Leante-CastellanosEnrique Jiménez-Santos
Jul 30, 2014·Methods in Enzymology·Alexei DegterevJunying Yuan
Aug 27, 2014·The American Journal of Gastroenterology·Thomas Damgaard SandahlHendrik Vilstrup
Aug 28, 2014·Seminars in Cell & Developmental Biology·Sandrine Jouan-LanhouetPeter Vandenabeele
Sep 6, 2014·Nature Reviews. Drug Discovery·Mitchell P Fink, H Shaw Warren
Sep 13, 2014·Clinical Chemistry·Leo R Zacharski
Sep 18, 2014·Biochemical and Biophysical Research Communications·Jing ZhaoJianlin Wu
Sep 25, 2014·Cardiovascular Toxicology·Ping-Chun LiChih-Yang Huang
Sep 25, 2014·Journal of Internal Medicine·A E Roher
Oct 7, 2014·FEBS Letters·Javier Ochoa-Repáraz, Lloyd H Kasper
Oct 8, 2014·Current Opinion in Gastroenterology·Maryse DagenaisMaya Saleh
Oct 11, 2014·Pediatric Research·Michael P ShermanVictoria Niklas
Oct 17, 2014·Nature·Yong ShiQiusheng Gu
Oct 21, 2014·The FEBS Journal·Maria Feoktistova, Martin Leverkus
Oct 22, 2014·Cellular and Molecular Life Sciences : CMLS·Agnieszka PłóciennikowskaKatarzyna Kwiatkowska
Oct 22, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas B Kell, Etheresia Pretorius
Oct 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rama D YammaniKaren M Haas
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ray ZhangJohn B Hogenesch
Nov 2, 2014·Animal Health Research Reviews·Mark Lyte
Nov 5, 2014·Clinical Science·Javier Rodríguez-CarrioAna Suárez
Nov 6, 2014·Experimental and Therapeutic Medicine·Aihong MengYuna Shi
Nov 21, 2014·Aging·Etheresia PretoriusDouglas B Kell
Dec 3, 2014·Critical Reviews in Oncology/hematology·R M ThusharaK S Girish
Dec 3, 2014·Current Opinion in Biotechnology·Ruth Ann Luna, Jane A Foster
Dec 3, 2014·Trends in Biochemical Sciences·Liming Sun, Xiaodong Wang
Dec 4, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir ChobotLenka Kubicova
Dec 11, 2014·The Journal of Obstetrics and Gynaecology Research·Ranmalee AmarasekaraVajira H W Dissanayake
Dec 11, 2014·Annual Review of Immunology·Francis Ka-Ming ChanKenta Moriwaki
Dec 17, 2014·Science·Andrew E Armitage, Hal Drakesmith
Dec 20, 2014·Handbook of Experimental Pharmacology·Angela PirilloGiuseppe Danilo Norata
Jan 13, 2015·Infectious Disease Clinics of North America·Tanya M Monaghan
Jan 16, 2015·Current Opinion in Anaesthesiology·Jeff Simmons, Jean-Francois Pittet
Jan 17, 2015·Nature·Manolis Pasparakis, Peter Vandenabeele
Jan 30, 2015·Journal of Clinical Microbiology·W Michael Dunne
Jan 31, 2015·NeoReviews·Bin CaoIndira U Mysorekar
Feb 2, 2015·Microbes and Infection·David Ribet, Pascale Cossart
Feb 7, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·L WangJ Neukammer
Feb 7, 2015·Expert Review of Clinical Immunology·Stefan ZielenRalf Schubert
Feb 14, 2015·Metallomics : Integrated Biometal Science·Sargurunathan Subashchandrabose, Harry L T Mobley
Feb 18, 2015·The Journal of Clinical Investigation·Emeran A MayerArpana Gupta
Feb 24, 2015·Clinical Biochemistry·Alexander BerezinPeter Kruzliak
Feb 26, 2015·Pharmacology, Biochemistry, and Behavior·Brijesh G TaksandeNandkishor R Kotagale
Feb 28, 2015·Nature Communications·Birgit LuefJillian F Banfield
Mar 1, 2015·FEMS Microbiology Reviews·M Sloan SiegristCarolyn R Bertozzi
Mar 6, 2015·Journal of Visualized Experiments : JoVE·Chun YangPierre Hardy
Mar 17, 2015·Arthritis Research & Therapy·Ae R NoortSander W Tas
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Adam DenesDavid Brough
Mar 19, 2015·Journal of Toxicology and Environmental Health. Part a·Qi XiongChaoying Li
Mar 27, 2015·Journal of Natural Science, Biology, and Medicine·Gaffar Sarwar Zaman, Fawzia Zaman
Apr 4, 2015·Experimental & Molecular Medicine·A-Jin LeeJae-Hong Kim
Apr 4, 2015·Science·Wendy S Garrett
Apr 8, 2015·The Journal of Surgical Research·Emily F MiduraMichael D Goodman
Apr 11, 2015·Cell·Vanessa Ridaura, Yasmine Belkaid
Apr 22, 2015·Seminars in Immunopathology·Pedro H V SaavedraMohamed Lamkanfi
May 6, 2015·FEMS Microbiology Reviews·Marnie PotgieterEtheresia Pretorius
May 13, 2015·Seminars in Thrombosis and Hemostasis·Elena NiccolaiDomenico Prisco
May 21, 2015·Nature Reviews. Neuroscience·Frank L HeppnerBurkhard Becher
May 24, 2015·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Debra Brandon, Jacqueline M McGrath
Jun 2, 2015·Frontiers in Immunology·Karin de Punder, Leo Pruimboom
Jun 23, 2015·Cell·Marielle S KöberlinGiulio Superti-Furga
Jun 30, 2015·BioMed Research International·Nidia Leon-SicairosAdrian Canizalez-Román
Jul 16, 2015·Nutrition Reviews·John BienenstockPaul Forsythe
Jul 21, 2015·Nature Reviews. Microbiology·Peter LiehlMaria M Mota
Jul 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Noortje IjssennaggerRoelof van der Meer
Aug 5, 2015·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Xiaomei CongJacqueline M McGrath
Aug 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daniel B DiGiulioDavid A Relman


Feb 27, 2016·Drug Discovery Today·Somdutta SahaJames R Brown
Oct 8, 1999·Biophysical Journal·D Raucher, M P Sheetz
Apr 20, 2016·Methods : a Companion to Methods in Enzymology·Boris L ZybailovKevin D Raney
Oct 19, 2016·Journal of Molecular Biology·Patricia Perez-Arnaiz, Daniel L Kaplan
Feb 9, 2016·Expert Review of Hematology·Sofiane TariketFabrice Cognasse
Jun 1, 2017·Journal of Chemical Theory and Computation·Li XiaoRay Luo
Dec 8, 2017·Frontiers in Immunology·Peter HolzerFlorian Reichmann
Nov 4, 2017·Cardiovascular Diabetology·Etheresia PretoriusDouglas B Kell
Sep 25, 2016·Disease Models & Mechanisms·Jan OlssonEloise H Kok
Feb 5, 2019·Journal of Clinical Laboratory Analysis·Jing QiuChen Dong
Apr 25, 2019·Journal of Medical Virology·Xiaolin DingBo Qin
Feb 23, 2016·Veterinary Medicine and Science·J Mark Craig