On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

Integrative Biology : Quantitative Biosciences From Nano to Macro
Douglas B Kell, Etheresia Pretorius

Abstract

We have recently highlighted (and added to) the considerable evidence that blood can contain dormant bacteria. By definition, such bacteria may be resuscitated (and thus proliferate). This may occur under conditions that lead to or exacerbate chronic, inflammatory diseases that are normally considered to lack a microbial component. Bacterial cell wall components, such as the endotoxin lipopolysaccharide (LPS) of Gram-negative strains, are well known as potent inflammatory agents, but should normally be cleared. Thus, their continuing production and replenishment from dormant bacterial reservoirs provides an easy explanation for the continuing, low-grade inflammation (and inflammatory cytokine production) that is characteristic of many such diseases. Although experimental conditions and determinants have varied considerably between investigators, we summarise the evidence that in a great many circumstances LPS can play a central role in all of these processes, including in particular cell death processes that permit translocation between the gut, blood and other tissues. Such localised cell death processes might also contribute strongly to the specific diseases of interest. The bacterial requirement for free iron explains the st...Continue Reading

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Nov 19, 2013·PloS One·Sten Braesch-AndersenMakiko Kumagai-Braesch
Dec 3, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G LuoA S Ibrahim
Dec 4, 2013·Current Opinion in Endocrinology, Diabetes, and Obesity·Giles Major, Robin Spiller
Dec 11, 2013·Frontiers in Cellular and Infection Microbiology·Larissa D Cunha, Dario S Zamboni
Dec 12, 2013·Journal of Neuroinflammation·Steven F AbcouwerDavid A Antonetti
Dec 19, 2013·PLoS Pathogens·Migla MiskinyteIsabel Gordo
Dec 21, 2013·Nature·Gilad DoitshWarner C Greene
Dec 25, 2013·PLoS Pathogens·Christopher N LaRock, Brad T Cookson
Dec 29, 2013·Brain, Behavior, and Immunity·Yan Wang, Lloyd H Kasper
Jan 7, 2014·Molecular Neurodegeneration·Leon M TaiMary Jo LaDu
Jan 7, 2014·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·C L LiuZ Y Sun
Jan 25, 2014·American Journal of Respiratory and Critical Care Medicine·Sachin YendeDerek C Angus
Feb 4, 2014·Infectious Disease Clinics of North America·Betsy Foxman
Feb 5, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Lisa F StinsonJeffrey A Keelan
Feb 8, 2014·PloS One·Xinlin Chen, Pingyan Chen
Feb 18, 2014·Journal of Neuroimmunology·Teresa TrottaMaria Antonietta Panaro
Feb 20, 2014·Metallomics : Integrated Biometal Science·Douglas B Kell, Etheresia Pretorius
Feb 26, 2014·Trends in Microbiology·Haripriya Sridharan, Jason W Upton
Mar 4, 2014·Trends in Molecular Medicine·John C Marshall
Mar 19, 2014·Trends in Molecular Medicine·Sachin YendeDerek C Angus
Mar 22, 2014·Neuroscience Bulletin·Evan DoreyWandong Zhang
Mar 25, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Angel Vila-CorcolesEPIVAC Research Group
Apr 5, 2014·Expert Opinion on Drug Discovery·Christian LehmannCharles C Caldwell
Apr 10, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Etheresia Pretorius, Douglas B Kell
Apr 18, 2014·Clinical and Experimental Pharmacology & Physiology·Zheng WuXi Lin
Apr 24, 2014·The Journal of Physiology·Giada De PalmaElena F Verdu
Jan 10, 2012·Journal of Chemical Education·Manish SudShankar Subramaniam
May 9, 2014·Future Microbiology·Frances Valencia-Shelton, Michael Loeffelholz
May 14, 2014·Prion·Fozia SaleemDavid S Wishart
May 23, 2014·Science Translational Medicine·Kjersti AagaardJames Versalovic
May 27, 2014·Cell·Mohamed Lamkanfi, Vishva M Dixit
Jun 13, 2014·Gut Microbes·Giada De PalmaPremysl Bercik
Jun 18, 2014·Cardiovascular Research·Alberico Luigi CatapanoGiuseppe Danilo Norata
Jul 6, 2014·Advances in Experimental Medicine and Biology·Mark Lyte
Jul 6, 2014·Advances in Experimental Medicine and Biology·Peter Holzer, Aitak Farzi
Jul 6, 2014·Advances in Experimental Medicine and Biology·Premysl Bercik, Stephen M Collins
Jul 6, 2014·Advances in Experimental Medicine and Biology·Mélanie G Gareau
Jul 12, 2014·Journal of Perinatal Medicine·José Luis Leante-CastellanosEnrique Jiménez-Santos
Jul 30, 2014·Methods in Enzymology·Alexei DegterevJunying Yuan
Aug 27, 2014·The American Journal of Gastroenterology·Thomas Damgaard SandahlHendrik Vilstrup
Aug 28, 2014·Seminars in Cell & Developmental Biology·Sandrine Jouan-LanhouetPeter Vandenabeele
Sep 6, 2014·Nature Reviews. Drug Discovery·Mitchell P Fink, H Shaw Warren
Sep 13, 2014·Clinical Chemistry·Leo R Zacharski
Sep 18, 2014·Biochemical and Biophysical Research Communications·Jing ZhaoJianlin Wu
Sep 25, 2014·Cardiovascular Toxicology·Ping-Chun LiChih-Yang Huang
Sep 25, 2014·Journal of Internal Medicine·A E Roher
Oct 7, 2014·FEBS Letters·Javier Ochoa-Repáraz, Lloyd H Kasper
Oct 8, 2014·Current Opinion in Gastroenterology·Maryse DagenaisMaya Saleh
Oct 11, 2014·Pediatric Research·Michael P ShermanVictoria Niklas
Oct 17, 2014·Nature·Yong ShiQiusheng Gu
Oct 21, 2014·The FEBS Journal·Maria Feoktistova, Martin Leverkus
Oct 22, 2014·Cellular and Molecular Life Sciences : CMLS·Agnieszka PłóciennikowskaKatarzyna Kwiatkowska
Oct 22, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Douglas B Kell, Etheresia Pretorius
Oct 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rama D YammaniKaren M Haas
Oct 29, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ray ZhangJohn B Hogenesch
Nov 2, 2014·Animal Health Research Reviews·Mark Lyte
Nov 5, 2014·Clinical Science·Javier Rodríguez-CarrioAna Suárez
Nov 6, 2014·Experimental and Therapeutic Medicine·Aihong MengYuna Shi
Nov 21, 2014·Aging·Etheresia PretoriusDouglas B Kell
Dec 3, 2014·Critical Reviews in Oncology/hematology·R M ThusharaK S Girish
Dec 3, 2014·Current Opinion in Biotechnology·Ruth Ann Luna, Jane A Foster
Dec 3, 2014·Trends in Biochemical Sciences·Liming Sun, Xiaodong Wang
Dec 4, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Vladimir ChobotLenka Kubicova
Dec 11, 2014·The Journal of Obstetrics and Gynaecology Research·Ranmalee AmarasekaraVajira H W Dissanayake
Dec 11, 2014·Annual Review of Immunology·Francis Ka-Ming ChanKenta Moriwaki
Dec 17, 2014·Science·Andrew E Armitage, Hal Drakesmith
Dec 20, 2014·Handbook of Experimental Pharmacology·Angela PirilloGiuseppe Danilo Norata
Jan 13, 2015·Infectious Disease Clinics of North America·Tanya M Monaghan
Jan 16, 2015·Current Opinion in Anaesthesiology·Jeff Simmons, Jean-Francois Pittet
Jan 17, 2015·Nature·Manolis Pasparakis, Peter Vandenabeele
Jan 30, 2015·Journal of Clinical Microbiology·W Michael Dunne
Jan 31, 2015·NeoReviews·Bin CaoIndira U Mysorekar
Feb 2, 2015·Microbes and Infection·David Ribet, Pascale Cossart
Feb 7, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·L WangJ Neukammer
Feb 7, 2015·Expert Review of Clinical Immunology·Stefan ZielenRalf Schubert
Feb 14, 2015·Metallomics : Integrated Biometal Science·Sargurunathan Subashchandrabose, Harry L T Mobley
Feb 18, 2015·The Journal of Clinical Investigation·Emeran A MayerArpana Gupta
Feb 24, 2015·Clinical Biochemistry·Alexander BerezinPeter Kruzliak
Feb 26, 2015·Pharmacology, Biochemistry, and Behavior·Brijesh G TaksandeNandkishor R Kotagale
Feb 28, 2015·Nature Communications·Birgit LuefJillian F Banfield
Mar 1, 2015·FEMS Microbiology Reviews·M Sloan SiegristCarolyn R Bertozzi
Mar 6, 2015·Journal of Visualized Experiments : JoVE·Chun YangPierre Hardy
Mar 17, 2015·Arthritis Research & Therapy·Ae R NoortSander W Tas
Mar 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Adam DenesDavid Brough
Mar 19, 2015·Journal of Toxicology and Environmental Health. Part a·Qi XiongChaoying Li
Mar 27, 2015·Journal of Natural Science, Biology, and Medicine·Gaffar Sarwar Zaman, Fawzia Zaman
Apr 4, 2015·Experimental & Molecular Medicine·A-Jin LeeJae-Hong Kim
Apr 4, 2015·Science·Wendy S Garrett
Apr 8, 2015·The Journal of Surgical Research·Emily F MiduraMichael D Goodman
Apr 11, 2015·Cell·Vanessa Ridaura, Yasmine Belkaid
Apr 22, 2015·Seminars in Immunopathology·Pedro H V SaavedraMohamed Lamkanfi
May 6, 2015·FEMS Microbiology Reviews·Marnie PotgieterEtheresia Pretorius
May 13, 2015·Seminars in Thrombosis and Hemostasis·Elena NiccolaiDomenico Prisco
May 21, 2015·Nature Reviews. Neuroscience·Frank L HeppnerBurkhard Becher
May 24, 2015·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Debra Brandon, Jacqueline M McGrath
Jun 2, 2015·Frontiers in Immunology·Karin de Punder, Leo Pruimboom
Jun 23, 2015·Cell·Marielle S KöberlinGiulio Superti-Furga
Jun 30, 2015·BioMed Research International·Nidia Leon-SicairosAdrian Canizalez-Román
Jul 16, 2015·Nutrition Reviews·John BienenstockPaul Forsythe
Jul 21, 2015·Nature Reviews. Microbiology·Peter LiehlMaria M Mota
Jul 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Noortje IjssennaggerRoelof van der Meer
Aug 5, 2015·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Xiaomei CongJacqueline M McGrath
Aug 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Daniel B DiGiulioDavid A Relman

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